STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pldPhospholipase D; Virulence factor affecting bacterial dissemination and survival within the host. Has magnesium-dependent catalytic activity toward sphingomyelin (SM) and acyl- and alkyl-lysophosphatidylcholine (LPC), but not toward sphingosylphosphorylcholine (SPC) and phosphatidylcholine (PC). Lysophosphatidic acid (LPA), assumed to result from LPC hydrolysis, evokes pathophysiological responses after LPA receptor internalization. Shows hemolytic activity. (307 aa)    
Predicted Functional Partners:
fagD
Iron-siderophore binding protein.
      
 0.661
rpoB
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
      
 0.661
nanH
Sialidase.
      
 0.661
pepD
Serine protease.
      
 0.648
dtxR
Diphtheria toxin repressor.
      
 0.648
tox
Diphtheria toxin.
      
 0.613
tpiA
Triosephosphate isomerase (TIM); Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
      
 0.613
spaF
Surface-anchored protein, fimbrial subunit.
      
 0.613
sodC
Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.
      
 0.605
glxR
CRP/FNR family transcriptional regulator.
      
 0.589
Your Current Organism:
Corynebacterium ulcerans
NCBI taxonomy Id: 65058
Other names: ATCC 51799, C. ulcerans, CCUG 2708, CIP 106504, DSM 46325, IMET 11148, JCM 10387, NCTC 7910, PCM 554, PCM:554
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