STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU43132.1TIGRFAM: isocitrate dehydrogenase, NADP-dependent; KEGG: bja:blr5747 isocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (408 aa)    
Predicted Functional Partners:
ADU42077.1
Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
  
 0.990
ADU42090.1
KEGG: bbt:BBta_0395 2-oxoglutarate dehydrogenase E1 component; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: Transketolase central region; dehydrogenase E1 component.
  
 
 0.985
ADU43098.1
Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
  
 0.964
mdh
Malate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
 
 0.933
ADU45769.1
PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: pth:PTH_0847 pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit.
   
 
 0.922
ADU45768.1
PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: dap:Dacet_2341 thiamine pyrophosphate protein domain protein TPP-binding protein.
     
 0.919
ADU44184.1
KEGG: bra:BRADO4126 type II citrate synthase; TIGRFAM: citrate synthase I; PFAM: Citrate synthase; Belongs to the citrate synthase family.
  
 
 0.915
aceK
(Isocitrate dehydrogenase (NADP(+))) kinase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
   
 
 0.909
ADU45767.1
PFAM: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; KEGG: ddf:DEFDS_0925 2-oxoglutarate ferredoxin oxidoreductase subunit gamma.
     
 0.908
sucC
succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
  
 0.903
Your Current Organism:
Rhodopseudomonas palustris DX1
NCBI taxonomy Id: 652103
Other names: R. palustris DX-1, Rhodopseudomonas palustris DX-1, Rhodopseudomonas palustris str. DX-1, Rhodopseudomonas palustris strain DX-1
Server load: high (82%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.