STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SES23595.1Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. (528 aa)    
Predicted Functional Partners:
SES35187.1
Acetolactate synthase, small subunit.
 0.996
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.992
SES13943.1
Acetolactate synthase, small subunit.
 
 0.985
SEQ82367.1
2-oxoglutarate ferredoxin oxidoreductase subunit beta.
  
 
 0.902
SES34765.1
L-threonine ammonia-lyase.
  
 0.886
SEQ82345.1
2-oxoglutarate ferredoxin oxidoreductase subunit alpha.
  
 
 0.881
SES44646.1
Threonine dehydratase.
  
 0.880
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
 0.875
SER81379.1
Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase.
 0.874
ilvD
Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family.
  
 0.872
Your Current Organism:
Lentzea albida
NCBI taxonomy Id: 65499
Other names: Asiosporangium albidum, DSM 44437, IFO 16102, JCM 10670, L. albida, Lentzea albida Labeda et al. 2001, NBRC 16102, NRRL B-24073, Saccharothrix aerocolonigenes subsp. staurosporea, Streptomyces stauroporeus, Streptomyces staurosporeus
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.