node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LLO_0018 | LLO_0020 | LLO_0018 | LLO_0020 | Hypothetical protein of unknown function; Equals llo0018. | Putative thiol-disulfide oxidoreductase; Equals llo0020. | 0.424 |
LLO_0018 | tdk | LLO_0018 | LLO_0019 | Hypothetical protein of unknown function; Equals llo0018. | Putative thymidine kinase; Equals llo0019. | 0.595 |
LLO_0020 | LLO_0018 | LLO_0020 | LLO_0018 | Putative thiol-disulfide oxidoreductase; Equals llo0020. | Hypothetical protein of unknown function; Equals llo0018. | 0.424 |
LLO_0020 | tdk | LLO_0020 | LLO_0019 | Putative thiol-disulfide oxidoreductase; Equals llo0020. | Putative thymidine kinase; Equals llo0019. | 0.586 |
LLO_2198 | cdd | LLO_2198 | LLO_1784 | Putative thymidine/pyrimidine-nucleoside phosphorylase; Equals llo2198. | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | 0.959 |
LLO_2198 | surE | LLO_2198 | LLO_1149 | Putative thymidine/pyrimidine-nucleoside phosphorylase; Equals llo2198. | Acid phosphatase SurE (Stationary phase survival protein); Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.928 |
LLO_2198 | tdk | LLO_2198 | LLO_0019 | Putative thymidine/pyrimidine-nucleoside phosphorylase; Equals llo2198. | Putative thymidine kinase; Equals llo0019. | 0.933 |
LLO_2198 | thyA | LLO_2198 | LLO_0184 | Putative thymidine/pyrimidine-nucleoside phosphorylase; Equals llo2198. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.414 |
cdd | LLO_2198 | LLO_1784 | LLO_2198 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Putative thymidine/pyrimidine-nucleoside phosphorylase; Equals llo2198. | 0.959 |
cdd | surE | LLO_1784 | LLO_1149 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Acid phosphatase SurE (Stationary phase survival protein); Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.910 |
cdd | tdk | LLO_1784 | LLO_0019 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Putative thymidine kinase; Equals llo0019. | 0.938 |
dut | surE | LLO_3062 | LLO_1149 | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (dUTP pyrophosphatase); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Acid phosphatase SurE (Stationary phase survival protein); Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.912 |
dut | tdk | LLO_3062 | LLO_0019 | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (dUTP pyrophosphatase); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Putative thymidine kinase; Equals llo0019. | 0.975 |
dut | thyA | LLO_3062 | LLO_0184 | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (dUTP pyrophosphatase); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.969 |
dut | tmk | LLO_3062 | LLO_1487 | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (dUTP pyrophosphatase); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Putative thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.947 |
prfA | pyrG | LLO_0559 | LLO_1039 | Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.665 |
prfA | tdk | LLO_0559 | LLO_0019 | Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | Putative thymidine kinase; Equals llo0019. | 0.801 |
pyrG | prfA | LLO_1039 | LLO_0559 | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | 0.665 |
pyrG | surE | LLO_1039 | LLO_1149 | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | Acid phosphatase SurE (Stationary phase survival protein); Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.416 |
pyrG | tdk | LLO_1039 | LLO_0019 | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | Putative thymidine kinase; Equals llo0019. | 0.597 |