| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AIL69403.1 | VV2879 | VV93_v1c03040 | VV93_v1c25850 | annotation not available | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family | 0.498 |
| AIL69403.1 | guaA | VV93_v1c03040 | VV93_v1c07220 | annotation not available | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP | 0.981 |
| AIL69403.1 | lysS | VV93_v1c03040 | VV93_v1c06080 | annotation not available | annotation not available | 0.518 |
| AIL69403.1 | purD | VV93_v1c03040 | VV93_v1c28610 | annotation not available | annotation not available | 0.419 |
| AIL69403.1 | purL | VV93_v1c03040 | VV93_v1c07870 | annotation not available | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate | 0.725 |
| VV2769 | VV2879 | VV93_v1c24810 | VV93_v1c25850 | annotation not available | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family | 0.906 |
| VV2769 | apt | VV93_v1c24810 | VV93_v1c21190 | annotation not available | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | 0.912 |
| VV2769 | guaA | VV93_v1c24810 | VV93_v1c07220 | annotation not available | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP | 0.981 |
| VV2769 | guaB | VV93_v1c24810 | VV93_v1c07210 | annotation not available | Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family | 0.949 |
| VV2769 | guaC | VV93_v1c24810 | VV93_v1c41090 | annotation not available | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides | 0.922 |
| VV2769 | purL | VV93_v1c24810 | VV93_v1c07870 | annotation not available | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate | 0.498 |
| VV2879 | AIL69403.1 | VV93_v1c25850 | VV93_v1c03040 | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family | annotation not available | 0.498 |
| VV2879 | VV2769 | VV93_v1c25850 | VV93_v1c24810 | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family | annotation not available | 0.906 |
| VV2879 | guaA | VV93_v1c25850 | VV93_v1c07220 | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP | 0.974 |
| VV2879 | guaB | VV93_v1c25850 | VV93_v1c07210 | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family | Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family | 0.989 |
| VV2879 | guaC | VV93_v1c25850 | VV93_v1c41090 | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides | 0.539 |
| apt | VV2769 | VV93_v1c21190 | VV93_v1c24810 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | annotation not available | 0.912 |
| apt | guaA | VV93_v1c21190 | VV93_v1c07220 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP | 0.994 |
| apt | guaB | VV93_v1c21190 | VV93_v1c07210 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family | 0.781 |
| apt | guaC | VV93_v1c21190 | VV93_v1c41090 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides | 0.965 |
