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Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Node Content
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VV1404
annotation not available (309 aa)
Predicted Functional Partners:
VV1403
annotation not available
0.813
AIL70406.1
annotation not available
0.727
AIL70407.1
annotation not available
0.548
mnmC
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC; Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34; In the N-terminal section; belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)- methyltransferase family
0.544
VV1402
annotation not available
0.515
rlmM
Ribosomal RNA large subunit methyltransferase M; Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
0.513
rlmN
Dual-specificity RNA methyltransferase RlmN; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family
0.475
VVA0783
annotation not available
0.467
cmoB
tRNA U34 carboxymethyltransferase; Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs
0.447
trmJ
tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
a tab-delimited file describing the names, domains and annotated functions of the network proteins
Browse interactions in tabular form:
node1
node2
node1 accession
node2 accession
node1 annotation
node2 annotation
score
AIL70406.1
AIL70407.1
VV93_v1c13160
VV93_v1c13170
annotation not available
annotation not available
0.681
AIL70406.1
VV1402
VV93_v1c13160
VV93_v1c13130
annotation not available
annotation not available
0.452
AIL70406.1
VV1403
VV93_v1c13160
VV93_v1c13140
annotation not available
annotation not available
0.675
AIL70406.1
VV1404
VV93_v1c13160
VV93_v1c13150
annotation not available
annotation not available
0.727
AIL70407.1
AIL70406.1
VV93_v1c13170
VV93_v1c13160
annotation not available
annotation not available
0.681
AIL70407.1
VV1403
VV93_v1c13170
VV93_v1c13140
annotation not available
annotation not available
0.512
AIL70407.1
VV1404
VV93_v1c13170
VV93_v1c13150
annotation not available
annotation not available
0.548
VV1402
AIL70406.1
VV93_v1c13130
VV93_v1c13160
annotation not available
annotation not available
0.452
VV1402
VV1403
VV93_v1c13130
VV93_v1c13140
annotation not available
annotation not available
0.552
VV1402
VV1404
VV93_v1c13130
VV93_v1c13150
annotation not available
annotation not available
0.515
VV1403
AIL70406.1
VV93_v1c13140
VV93_v1c13160
annotation not available
annotation not available
0.675
VV1403
AIL70407.1
VV93_v1c13140
VV93_v1c13170
annotation not available
annotation not available
0.512
VV1403
VV1402
VV93_v1c13140
VV93_v1c13130
annotation not available
annotation not available
0.552
VV1403
VV1404
VV93_v1c13140
VV93_v1c13150
annotation not available
annotation not available
0.813
VV1404
AIL70406.1
VV93_v1c13150
VV93_v1c13160
annotation not available
annotation not available
0.727
VV1404
AIL70407.1
VV93_v1c13150
VV93_v1c13170
annotation not available
annotation not available
0.548
VV1404
VV1402
VV93_v1c13150
VV93_v1c13130
annotation not available
annotation not available
0.515
VV1404
VV1403
VV93_v1c13150
VV93_v1c13140
annotation not available
annotation not available
0.813
VV1404
VVA0783
VV93_v1c13150
VV93_v1c37730
annotation not available
annotation not available
0.467
VV1404
cmoB
VV93_v1c13150
VV93_v1c20010
annotation not available
tRNA U34 carboxymethyltransferase; Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs
0.447
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Network Stats
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Functional enrichments in your networkNote: some enrichments may be expected here (why?) explain columns
Enrichment analysis is still ongoing, please wait ...
Statistical background
For the above enrichment analysis, the following statistical background is assumed: