Automated, unsupervised textmining - searching for proteins that are frequently mentioned together.
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Fusion
Genes that are sometimes fused into single open reading frames.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Node Content
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VV1720
annotation not available (196 aa)
Predicted Functional Partners:
nagK
N-acetyl-D-glucosamine kinase; Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P
a tab-delimited file describing the names, domains and annotated functions of the network proteins
Browse interactions in tabular form:
node1
node2
node1 accession
node2 accession
node1 annotation
node2 annotation
score
AIL69252.1
VV1720
VV93_v1c01520
VV93_v1c16120
annotation not available
annotation not available
0.485
VV0164
VV1720
VV93_v1c35080
VV93_v1c16120
annotation not available
annotation not available
0.485
VV1720
AIL69252.1
VV93_v1c16120
VV93_v1c01520
annotation not available
annotation not available
0.485
VV1720
VV0164
VV93_v1c16120
VV93_v1c35080
annotation not available
annotation not available
0.485
VV1720
VV1721
VV93_v1c16120
VV93_v1c16130
annotation not available
annotation not available
0.425
VV1720
nagK
VV93_v1c16120
VV93_v1c16110
annotation not available
N-acetyl-D-glucosamine kinase; Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P
0.490
VV1720
sbcB
VV93_v1c16120
VV93_v1c13810
annotation not available
annotation not available
0.461
VV1721
VV1720
VV93_v1c16130
VV93_v1c16120
annotation not available
annotation not available
0.425
nagK
VV1720
VV93_v1c16110
VV93_v1c16120
N-acetyl-D-glucosamine kinase; Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P
annotation not available
0.490
sbcB
VV1720
VV93_v1c13810
VV93_v1c16120
annotation not available
annotation not available
0.461
Network Stats
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Functional enrichments in your networkNote: some enrichments may be expected here (why?) explain columns
Enrichment analysis is still ongoing, please wait ...
Statistical background
For the above enrichment analysis, the following statistical background is assumed: