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lepA protein (Pseudonocardia dioxanivorans) - STRING interaction network
"lepA" - GTP-binding protein LepA in Pseudonocardia dioxanivorans
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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lepAGTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (618 aa)    
Predicted Functional Partners:
prfA
Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (366 aa)
 
   
  0.898
Psed_0280
alanyl-tRNA synthetase (463 aa)
 
   
  0.856
rplM
50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (147 aa)
 
 
  0.844
rpsI
30S ribosomal protein S9 (201 aa)
 
   
  0.830
der
GTP-binding protein engA; GTPase that plays an essential role in the late steps of ribosome biogenesis (486 aa)
 
 
  0.814
rplQ
50S ribosomal protein L17 (245 aa)
   
 
  0.807
obg
GTPase obg; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control (523 aa)
 
   
  0.804
rplP
50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (139 aa)
   
   
  0.802
pheS
Phenylalanyl-tRNA synthetase subunit alpha (366 aa)
   
   
  0.798
Psed_3570
aspartyl-tRNA synthetase (594 aa)
 
   
  0.795
Your Current Organism:
Pseudonocardia dioxanivorans
NCBI taxonomy Id: 675635
Other names: Actinobispora, Amycolata, P. dioxanivorans, P. dioxanivorans CB1190, Pseudamycolata, Pseudoamycolata, Pseudonocardia, Pseudonocardia dioxanivorans, Pseudonocardia dioxanivorans CB1190, Pseudonocardia dioxanivorans DSM 44775, Pseudonocardia dioxanivorans Mahendra and Alvarez-Cohen 2005, Pseudonocardia dioxanivorans str. CB1190, Pseudonocardia dioxanivorans strain CB1190
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