STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Psed_4718PFAM: DNA ligase, ATP-dependent, central; DNA ligase, ATP-dependent, C-terminal; KEGG: mpa:MAP0341 ATP-dependent DNA ligase. (356 aa)    
Predicted Functional Partners:
Psed_2901
KEGG: sen:SACE_1849 DNA ligase (ATP); TIGRFAM: DNA polymerase LigD, polymerase domain; PFAM: DNA primase, small subunit.
   
 0.947
Psed_4714
DNA primase small subunit; KEGG: rop:ROP_52850 hypothetical protein; manually curated; PFAM: DNA primase, small subunit.
   
 0.920
ku
Ku protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.893
ku-2
DNA repair protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.883
Psed_0303
KEGG: mau:Micau_5172 DNA polymerase LigD polymerase subunit; TIGRFAM: DNA polymerase LigD, polymerase domain; PFAM: DNA primase, small subunit.
   
 0.850
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.842
Psed_3283
5'-3' exonuclease, resolvase-like domain-containing protein; KEGG: ami:Amir_2257 5'-3' exonuclease; PFAM: 5'-3' exonuclease, alpha-helical arch, N-terminal; 5'-3' exonuclease, SAM-fold domain; SMART: 5'-3' exonuclease, N-terminal; Helix-hairpin-helix motif, class 2.
 
 0.835
Psed_3272
KEGG: amd:AMED_3255 ATP-dependent DNA ligase; TIGRFAM: DNA polymerase LigD, polymerase domain; DNA ligase D, 3'-phosphoesterase domain; PFAM: DNA primase, small subunit; DNA ligase, ATP-dependent, central.
   
 0.831
Psed_0002
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.795
ligA
DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
     
 0.795
Your Current Organism:
Pseudonocardia dioxanivorans
NCBI taxonomy Id: 675635
Other names: P. dioxanivorans CB1190, Pseudonocardia dioxanivorans CB1190, Pseudonocardia dioxanivorans DSM 44775, Pseudonocardia dioxanivorans str. CB1190, Pseudonocardia dioxanivorans strain CB1190
Server load: medium (56%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.