STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEH60240.1COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterProIPR016161:IPR016160:IPR016162:IPR015590:IPR 012394; KEGG: cth:Cthe_2238 aldehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: C4CSZ5 NAD-dependent aldehyde dehydrogenase; PFAM: Aldehyde dehydrogenase family. (489 aa)    
Predicted Functional Partners:
AEH60763.1
COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR000873:IPR020845; KEGG: mba:Mbar_A2172 AMP-binding protein; PFAM: AMP-dependent synthetase and ligase; SPTR: Q46AJ2 AMP-binding protein; PFAM: AMP-binding enzyme.
  
 0.946
acsA
acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 0.946
mfnA
Pyridoxal-dependent decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis; Belongs to the group II decarboxylase family. MfnA subfamily.
 
 0.941
AEH60693.1
Acetyl coenzyme A synthetase (ADP forming), alpha domain protein; COGs: COG1042 Acyl-CoA synthetase (NDP forming); InterProIPR003781:IPR005811:IPR016102:IPR016040:IPR 014089; KEGG: mbu:Mbur_1347 acyl-CoA synthetase; PFAM: CoA-binding domain protein; ATP-citrate lyase/succinyl-CoA ligase; SPTR: Q12WB1 Acetyl-CoA synthetase (ADP-forming), alpha and beta subunits; TIGRFAM: acetyl coenzyme A synthetase (ADP forming), alpha domain protein; PFAM: CoA binding domain; TIGRFAM: acetyl coenzyme A synthetase (ADP forming), alpha domain.
    
 0.921
AEH59889.1
COGs: COG2379 Putative glycerate kinase; InterPro IPR007835; KEGG: sfu:Sfum_3915 MOFRL domain-containing protein; PFAM: MOFRL domain protein; PRIAM: Glycerate kinase; SPTR: Q1PYP3 Putative uncharacterized protein; PFAM: MOFRL family.
  
 
 0.916
AEH61469.1
COGs: COG1254 Acylphosphatase; InterPro IPR001792:IPR017968; KEGG: mbu:Mbur_1323 acylphosphatase; PFAM: acylphosphatase; SPTR: Q12WD5 Acylphosphatase; PFAM: Acylphosphatase.
    
 0.915
AEH60369.1
Protein of unknown function DUF137; COGs: COG1701 conserved hypothetical protein; InterPro IPR002855; KEGG: mbu:Mbur_1184 hypothetical protein; PFAM: Protein of unknown function DUF137; SPTR: Q12WR9 Putative uncharacterized protein; PFAM: Protein of unknown function DUF137.
     
  0.900
AEH60225.1
COGs: COG0334 Glutamate dehydrogenase/leucine dehydrogenase; InterProIPR016040:IPR006095:IPR006097:IPR006096:IPR 014362; KEGG: mbu:Mbur_1973 glutamate dehydrogenase (NAD/NADP); PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; SPTR: Q12UM4 Glutamate dehydrogenase; PFAM: Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 0.862
AEH61848.1
Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR009014:IPR015941:IPR002880:IPR005476; KEGG: mbu:Mbur_2157 pyruvate ferredoxin oxidoreductase, alpha subunit; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Transketolase domain protein; SPTR: Q2Y4G6 Pyruvate synthase, alpha subunit; PFAM: domain; Transketolase, C-terminal domain.
   
 0.841
AEH60214.1
COGs: COG0174 Glutamine synthetase; InterPro IPR008147:IPR008146:IPR014746:IPR004809; KEGG: mbu:Mbur_1975 L-glutamine synthetase; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; PRIAM: Glutamate--ammonia ligase; SPTR: Q12UM2 Glutamine synthetase; TIGRFAM: glutamine synthetase, type I; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain; TIGRFAM: glutamine synthetase, type I.
  
 
 0.839
Your Current Organism:
Methanosalsum zhilinae
NCBI taxonomy Id: 679901
Other names: M. zhilinae DSM 4017, Methanosalsum zhilinae DSM 4017, Methanosalsum zhilinae str. DSM 4017, Methanosalsum zhilinae strain DSM 4017
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