STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
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[Homology]
Score
ligDNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (569 aa)    
Predicted Functional Partners:
AEH60552.1
PHP domain protein; COGs: COG1796 DNA polymerase IV (family X); InterProIPR004013:IPR016195:IPR010996:IPR010994:IPR 002008:IPR002054:IPR003583:IPR003141; KEGG: mba:Mbar_A1642 bifunctional DNA polymerase X family protein/histidinol phosphatase; PFAM: PHP domain protein; SMART: DNA polymerase X; Helix-hairpin-helix DNA-binding class 1; phosphoesterase PHP domain protein; SPTR: Q46C05 DNA polymerase X family / putative histidinol phosphatase; PFAM: PHP domain.
 
 0.954
AEH60948.1
DNA ligase D, 3'-phosphoesterase domain protein; InterPro IPR014144; KEGG: mpd:MCP_2127 hypothetical protein; SPTR: A6EH98 ATP-dependent DNA ligase; TIGRFAM: DNA ligase D, 3'-phosphoesterase domain protein; TIGRFAM: DNA ligase D, 3'-phosphoesterase domain.
   
 0.944
lig-2
DNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
  
  
 
0.911
pcn
Proliferating cell nuclear antigen PcnA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
   
 0.888
fen
Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...]
 
 0.861
AEH60103.1
COGs: COG0417 DNA polymerase elongation subunit (family B); InterProIPR017964:IPR006172:IPR012337:IPR006133:IPR 006134:IPR017966:IPR004578; KEGG: mbu:Mbur_1688 replicative DNA polymerase I; PFAM: DNA polymerase B region; DNA polymerase B exonuclease; PRIAM: DNA-directed DNA polymerase; SMART: DNA-directed DNA polymerase B; SPTR: Q12VE4 DNA polymerase; TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain; TIGRFAM: pentatricopeptide repeat domain (PPR motif); DNA polymerase (pol2).
  
 0.699
AEH60007.1
Endonuclease/exonuclease/phosphatase; COGs: COG0708 Exonuclease III; InterPro IPR005135; KEGG: exodeoxyribonuclease III family protein; PFAM: Endonuclease/exonuclease/phosphatase; SPTR: A8PFZ1 Exodeoxyribonuclease III family protein; PFAM: Endonuclease/Exonuclease/phosphatase family.
  
 
 0.628
polB
DNA-directed DNA polymerase; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family.
   
 
 0.625
AEH61145.1
Type III restriction protein res subunit; COGs: COG1061 DNA or RNA helicase of superfamily II; InterProIPR011990:IPR013026:IPR014021:IPR001650:IPR 006935:IPR014001; KEGG: hla:Hlac_3022 type III restriction protein res subunit; PFAM: type III restriction protein res subunit; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein; SPTR: B9LV54 Type III restriction protein res subunit; PFAM: Helicase conserved C-terminal domain; Type III restriction enzyme, res subunit.
  
 
 0.618
AEH60550.1
Geranylgeranyl reductase; COGs: COG0644 Dehydrogenase (flavoprotein); InterPro IPR006076:IPR003042:IPR011777; KEGG: mbu:Mbur_0303 geranylgeranyl reductase; PFAM: FAD dependent oxidoreductase; SPTR: Q12Z21 Oxidoreductase with FAD-binding domain; TIGRFAM: geranylgeranyl reductase; PFAM: Glucose inhibited division protein A; TIGRFAM: geranylgeranyl reductase family.
 
    0.607
Your Current Organism:
Methanosalsum zhilinae
NCBI taxonomy Id: 679901
Other names: M. zhilinae DSM 4017, Methanosalsum zhilinae DSM 4017, Methanosalsum zhilinae str. DSM 4017, Methanosalsum zhilinae strain DSM 4017
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