STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
AEH60763.1COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR000873:IPR020845; KEGG: mba:Mbar_A2172 AMP-binding protein; PFAM: AMP-dependent synthetase and ligase; SPTR: Q46AJ2 AMP-binding protein; PFAM: AMP-binding enzyme. (565 aa)    
Predicted Functional Partners:
AEH60532.1
2-methylcitrate synthase/citrate synthase II; COGs: COG0372 Citrate synthase; InterProIPR002020:IPR016141:IPR016142:IPR019810:IPR 011278; KEGG: mba:Mbar_A0715 citrate synthase; PFAM: Citrate synthase; PRIAM: Citrate (Si)-synthase; SPTR: Q46EJ9 Citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II.
  
 0.976
AEH60693.1
Acetyl coenzyme A synthetase (ADP forming), alpha domain protein; COGs: COG1042 Acyl-CoA synthetase (NDP forming); InterProIPR003781:IPR005811:IPR016102:IPR016040:IPR 014089; KEGG: mbu:Mbur_1347 acyl-CoA synthetase; PFAM: CoA-binding domain protein; ATP-citrate lyase/succinyl-CoA ligase; SPTR: Q12WB1 Acetyl-CoA synthetase (ADP-forming), alpha and beta subunits; TIGRFAM: acetyl coenzyme A synthetase (ADP forming), alpha domain protein; PFAM: CoA binding domain; TIGRFAM: acetyl coenzyme A synthetase (ADP forming), alpha domain.
    
 0.971
AEH61706.1
COGs: COG0183 Acetyl-CoA acetyltransferase; InterPro IPR002155:IPR016039:IPR016038; KEGG: mbu:Mbur_1933 acetyl-CoA acetyltransferase; SPTR: Q12UR2 Acetoacetyl-CoA thiolase; PFAM: Thiolase, C-terminal domain; Thiolase, N-terminal domain.
  
 
 0.956
AEH60240.1
COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterProIPR016161:IPR016160:IPR016162:IPR015590:IPR 012394; KEGG: cth:Cthe_2238 aldehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: C4CSZ5 NAD-dependent aldehyde dehydrogenase; PFAM: Aldehyde dehydrogenase family.
  
 0.946
AEH59916.1
Pyruvate carboxyltransferase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR002034:IPR013709:IPR000891:IPR013785; KEGG: mbu:Mbur_1781 2-isopropylmalate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; SPTR: Q2Y4F2 Probable 2-isopropylmalate synthase 2; PFAM: HMGL-like; LeuA allosteric (dimerisation) domain.
  
 
 0.928
AEH60997.1
Pyruvate carboxyltransferase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891:IPR002034:IPR013785; KEGG: mbu:Mbur_0854 trans-homoaconitate synthase; PFAM: pyruvate carboxyltransferase; SPTR: Q12XM1 (R)-citramalate synthase; PFAM: HMGL-like; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 
 0.928
cdhE
CO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy.
   
 
 0.925
cdhC
CO dehydrogenase/acetyl-CoA synthase complex, beta subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron- sulfur protein (the gamma-delta complex).
   
 
 0.924
AEH61849.1
Thiamine pyrophosphate protein domain protein TPP-binding protein; COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766; KEGG: mma:MM_1339 pyruvate synthase beta subunit; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; SPTR: Q2Y4G7 Pyruvate synthase, beta subunit; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain.
  
 
 0.922
acsA
acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
 
 
0.921
Your Current Organism:
Methanosalsum zhilinae
NCBI taxonomy Id: 679901
Other names: M. zhilinae DSM 4017, Methanosalsum zhilinae DSM 4017, Methanosalsum zhilinae str. DSM 4017, Methanosalsum zhilinae strain DSM 4017
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