STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCL52185.1DNA ligase D. (329 aa)    
Predicted Functional Partners:
SCL47516.1
Bifunctional non-homologous end joining protein LigD; Manually curated.
  
 0.992
SCL52213.1
ATP-dependent DNA ligase.
  
 0.975
ku
DNA end-binding protein Ku; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.906
SCL61613.1
DNA ligase-1.
  
 0.854
SCL47518.1
Bifunctional non-homologous end joining protein LigD.
 
  
 
0.757
SCL52182.1
Peptide-methionine (R)-S-oxide reductase; Belongs to the MsrB Met sulfoxide reductase family.
       0.618
ligA
DNA ligase (NAD+); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
     
 0.459
SCL51813.1
ATP dependent helicase, Lhr family.
  
     0.459
SCL53455.1
DNA topoisomerase IB; Manually curated.
 
     0.423
SCL66026.1
formamidopyrimidine-DNA glycosylase; Belongs to the FPG family.
  
     0.415
Your Current Organism:
Micromonospora yangpuensis
NCBI taxonomy Id: 683228
Other names: CGMCC 4.5736, DSM 45577, M. yangpuensis, Micromonospora sp. FXJ6.011, Micromonospora yangpuensis Zhang et al. 2012, NBRC 107727, strain FXJ6.011
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