node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
actA | hly1 | lse_0186 | lse_0183 | Actin-assembly inducing protein. | Listeriolysin O; Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation. | 0.819 |
actA | lse_2606 | lse_0186 | lse_2606 | Actin-assembly inducing protein. | Secreted protein, putative. | 0.765 |
actA | mpl | lse_0186 | lse_0185 | Actin-assembly inducing protein. | Zinc metallopeptidase; Extracellular zinc metalloprotease. | 0.914 |
actA | plcA | lse_0186 | lse_0182 | Actin-assembly inducing protein. | Phosphatidylinositol-specific phospholipase C. | 0.887 |
actA | plcB | lse_0186 | lse_0189 | Actin-assembly inducing protein. | Phospholipase. | 0.899 |
actA | prfA1 | lse_0186 | lse_0180 | Actin-assembly inducing protein. | Listeriolysin positive regulatory protein. | 0.676 |
hly1 | actA | lse_0183 | lse_0186 | Listeriolysin O; Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation. | Actin-assembly inducing protein. | 0.819 |
hly1 | lse_0394 | lse_0183 | lse_0394 | Listeriolysin O; Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation. | Leucine-rich repeat, cell wall anchor family protein. | 0.666 |
hly1 | lse_0546 | lse_0183 | lse_0546 | Listeriolysin O; Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation. | Cell wall surface anchor (LPXTG motif) family protein. | 0.681 |
hly1 | lse_1332 | lse_0183 | lse_1332 | Listeriolysin O; Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation. | Putative secreted protein. | 0.700 |
hly1 | lse_1634 | lse_0183 | lse_1634 | Listeriolysin O; Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation. | Cell wall surface anchor family protein, putative. | 0.703 |
hly1 | lse_2606 | lse_0183 | lse_2606 | Listeriolysin O; Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation. | Secreted protein, putative. | 0.795 |
hly1 | mpl | lse_0183 | lse_0185 | Listeriolysin O; Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation. | Zinc metallopeptidase; Extracellular zinc metalloprotease. | 0.879 |
hly1 | plcA | lse_0183 | lse_0182 | Listeriolysin O; Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation. | Phosphatidylinositol-specific phospholipase C. | 0.939 |
hly1 | plcB | lse_0183 | lse_0189 | Listeriolysin O; Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation. | Phospholipase. | 0.923 |
hly1 | prfA1 | lse_0183 | lse_0180 | Listeriolysin O; Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation. | Listeriolysin positive regulatory protein. | 0.759 |
lse_0394 | hly1 | lse_0394 | lse_0183 | Leucine-rich repeat, cell wall anchor family protein. | Listeriolysin O; Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation. | 0.666 |
lse_0394 | lse_0546 | lse_0394 | lse_0546 | Leucine-rich repeat, cell wall anchor family protein. | Cell wall surface anchor (LPXTG motif) family protein. | 0.777 |
lse_0394 | plcA | lse_0394 | lse_0182 | Leucine-rich repeat, cell wall anchor family protein. | Phosphatidylinositol-specific phospholipase C. | 0.408 |
lse_0394 | plcB | lse_0394 | lse_0189 | Leucine-rich repeat, cell wall anchor family protein. | Phospholipase. | 0.782 |