STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hly1Listeriolysin O; Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation. (530 aa)    
Predicted Functional Partners:
plcA
Phosphatidylinositol-specific phospholipase C.
 
  
 0.939
plcB
Phospholipase.
  
  
 0.923
mpl
Zinc metallopeptidase; Extracellular zinc metalloprotease.
 
  
 0.879
actA
Actin-assembly inducing protein.
  
  
 0.819
lse_2606
Secreted protein, putative.
  
  
 0.795
prfA1
Listeriolysin positive regulatory protein.
  
  
 0.759
lse_1634
Cell wall surface anchor family protein, putative.
  
  
 0.703
lse_1332
Putative secreted protein.
  
  
 0.700
lse_0546
Cell wall surface anchor (LPXTG motif) family protein.
 
    0.681
lse_0394
Leucine-rich repeat, cell wall anchor family protein.
  
  
 0.666
Your Current Organism:
Listeria seeligeri
NCBI taxonomy Id: 683837
Other names: L. seeligeri serovar 1/2b str. SLCC3954, Listeria seeligeri serovar 1/2b str. SLCC3954, Listeria seeligeri serovar 1/2b strain SLCC3954
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