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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEH51309.1MiaB-like tRNA modifying enzyme; COGs: COG0621 2-methylthioadenine synthetase; InterPro IPR005839:IPR006467:IPR006638:IPR020612:IPR013848:IPR0071 97; KEGG: tle:Tlet_1059 MiaB-like tRNA modifying enzyme; PFAM: protein of unknown function UPF0004; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: MiaB-like tRNA modifying enzyme; TIGRFAM: MiaB-like tRNA modifying enzyme; RNA modification enzyme, MiaB family; PFAM: Radical SAM superfamily; Uncharacterized protein family UPF0004; TIGRFAM: MiaB-like tRNA modifying enzyme; RNA modification enzyme, MiaB family. (434 aa)    
Predicted Functional Partners:
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
     
 0.833
AEH51308.1
Aminotransferase class IV; COGs: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; InterPro IPR018300:IPR001544; KEGG: tle:Tlet_1058 aminotransferase class IV; PFAM: aminotransferase class IV; SPTR: Aminotransferase class IV; PFAM: Aminotransferase class IV.
       0.824
AEH51304.1
Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family.
  
    0.817
AEH51307.1
Protein of unknown function DUF721; InterPro IPR007922; KEGG: tle:Tlet_1057 hypothetical protein; PFAM: protein of unknown function DUF721; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF721).
       0.811
AEH51310.1
Putative signal transduction protein with CBS domains; COGs: COG2524 transcriptional regulator protein; InterPro IPR000644; KEGG: tle:Tlet_1060 signal transduction protein; PFAM: CBS domain containing protein; SMART: CBS domain containing protein; SPTR: Putative signal transduction protein with CBS domains; manually curated; PFAM: CBS domain.
       0.811
AEH51312.1
ABC transporter related protein; COGs: COG4988 ABC-type transport system involved in cytochrome bd biosynthesis ATPase and permease components; InterPro IPR003439; KEGG: tle:Tlet_1062 ABC transporter related; PFAM: ABC transporter related; SPTR: ABC transporter related; PFAM: Archaeal ATPase.
       0.804
AEH51311.1
PfkB domain protein; COGs: COG1105 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB); InterPro IPR011611; KEGG: tle:Tlet_1061 ribokinase-like domain-containing protein; PFAM: PfkB domain protein; SPTR: PfkB domain protein; PFAM: pfkB family carbohydrate kinase; TIGRFAM: hexose kinase, 1-phosphofructokinase family.
       0.803
AEH51305.1
KEGG: tle:Tlet_1055 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.802
AEH51313.1
KEGG: kol:Kole_0344 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.771
AEH51301.1
KEGG: tle:Tlet_1051 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.763
Your Current Organism:
Pseudothermotoga thermarum
NCBI taxonomy Id: 688269
Other names: P. thermarum DSM 5069, Pseudothermotoga thermarum DSM 5069, Pseudothermotoga thermarum LA3, Pseudothermotoga thermarum str. DSM 5069, Pseudothermotoga thermarum strain DSM 5069, Thermotoga thermarum DSM 5069, Thermotoga thermarum LA3
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