node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
TK0259 | TK0268 | TK0259 | TK0268 | Prephenate dehydrogenase. | 2-dehydro-3-deoxyphosphoheptonate aldolase. | 0.803 |
TK0259 | TK0269 | TK0259 | TK0269 | Prephenate dehydrogenase. | Transketolase, C-terminal section. | 0.688 |
TK0259 | TK0270 | TK0259 | TK0270 | Prephenate dehydrogenase. | Transketolase, N-terminal section. | 0.697 |
TK0259 | TK0271 | TK0259 | TK0271 | Prephenate dehydrogenase. | Hypothetical protein, conserved. | 0.577 |
TK0259 | aroA | TK0259 | TK0263 | Prephenate dehydrogenase. | 5-enolpyruvylshikimate-3-phosphate synthase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.802 |
TK0259 | aroB | TK0259 | TK0267 | Prephenate dehydrogenase. | 3-dehydroquinate synthetase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 0.829 |
TK0259 | aroC | TK0259 | TK0262 | Prephenate dehydrogenase. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.858 |
TK0259 | aroD | TK0259 | TK0266 | Prephenate dehydrogenase. | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. | 0.780 |
TK0259 | aroE | TK0259 | TK0265 | Prephenate dehydrogenase. | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.761 |
TK0259 | aroK | TK0259 | TK0264 | Prephenate dehydrogenase. | Archaeal shikimate kinase. | 0.733 |
TK0268 | TK0259 | TK0268 | TK0259 | 2-dehydro-3-deoxyphosphoheptonate aldolase. | Prephenate dehydrogenase. | 0.803 |
TK0268 | TK0269 | TK0268 | TK0269 | 2-dehydro-3-deoxyphosphoheptonate aldolase. | Transketolase, C-terminal section. | 0.801 |
TK0268 | TK0270 | TK0268 | TK0270 | 2-dehydro-3-deoxyphosphoheptonate aldolase. | Transketolase, N-terminal section. | 0.801 |
TK0268 | TK0271 | TK0268 | TK0271 | 2-dehydro-3-deoxyphosphoheptonate aldolase. | Hypothetical protein, conserved. | 0.801 |
TK0268 | aroA | TK0268 | TK0263 | 2-dehydro-3-deoxyphosphoheptonate aldolase. | 5-enolpyruvylshikimate-3-phosphate synthase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.940 |
TK0268 | aroB | TK0268 | TK0267 | 2-dehydro-3-deoxyphosphoheptonate aldolase. | 3-dehydroquinate synthetase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 0.996 |
TK0268 | aroC | TK0268 | TK0262 | 2-dehydro-3-deoxyphosphoheptonate aldolase. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.912 |
TK0268 | aroD | TK0268 | TK0266 | 2-dehydro-3-deoxyphosphoheptonate aldolase. | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. | 0.876 |
TK0268 | aroE | TK0268 | TK0265 | 2-dehydro-3-deoxyphosphoheptonate aldolase. | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.897 |
TK0268 | aroK | TK0268 | TK0264 | 2-dehydro-3-deoxyphosphoheptonate aldolase. | Archaeal shikimate kinase. | 0.801 |