node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
TK0067 | TK1650 | TK0067 | TK1650 | Nicotinamide mononucleotide adenylyltransferase. | Probable nicotinamidase. | 0.812 |
TK0067 | cobB | TK0067 | TK0685 | Nicotinamide mononucleotide adenylyltransferase. | NAD-dependent protein deacetylase Sir2p homolog; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily. | 0.957 |
TK0067 | nadE | TK0067 | TK1798 | Nicotinamide mononucleotide adenylyltransferase. | NH3-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.959 |
TK0067 | nadK | TK0067 | TK2124 | Nicotinamide mononucleotide adenylyltransferase. | ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.922 |
TK0134 | cobB | TK0134 | TK0685 | Probable acetylpolyamine aminohydrolase, histon deacetylase family. | NAD-dependent protein deacetylase Sir2p homolog; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily. | 0.811 |
TK0686 | TK0687 | TK0686 | TK0687 | Hydrolase, HAD superfamily. | Hypothetical protein, conserved, DUF437 family. | 0.801 |
TK0686 | TK0688 | TK0686 | TK0688 | Hydrolase, HAD superfamily. | Membrane-associated phosphatase, PAP2 superfamily. | 0.802 |
TK0686 | cobB | TK0686 | TK0685 | Hydrolase, HAD superfamily. | NAD-dependent protein deacetylase Sir2p homolog; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily. | 0.752 |
TK0687 | TK0686 | TK0687 | TK0686 | Hypothetical protein, conserved, DUF437 family. | Hydrolase, HAD superfamily. | 0.801 |
TK0687 | TK0688 | TK0687 | TK0688 | Hypothetical protein, conserved, DUF437 family. | Membrane-associated phosphatase, PAP2 superfamily. | 0.750 |
TK0687 | cobB | TK0687 | TK0685 | Hypothetical protein, conserved, DUF437 family. | NAD-dependent protein deacetylase Sir2p homolog; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily. | 0.734 |
TK0688 | TK0686 | TK0688 | TK0686 | Membrane-associated phosphatase, PAP2 superfamily. | Hydrolase, HAD superfamily. | 0.802 |
TK0688 | TK0687 | TK0688 | TK0687 | Membrane-associated phosphatase, PAP2 superfamily. | Hypothetical protein, conserved, DUF437 family. | 0.750 |
TK0688 | cobB | TK0688 | TK0685 | Membrane-associated phosphatase, PAP2 superfamily. | NAD-dependent protein deacetylase Sir2p homolog; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily. | 0.672 |
TK1650 | TK0067 | TK1650 | TK0067 | Probable nicotinamidase. | Nicotinamide mononucleotide adenylyltransferase. | 0.812 |
TK1650 | cobB | TK1650 | TK0685 | Probable nicotinamidase. | NAD-dependent protein deacetylase Sir2p homolog; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily. | 0.933 |
TK1650 | nadE | TK1650 | TK1798 | Probable nicotinamidase. | NH3-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.715 |
cobB | TK0067 | TK0685 | TK0067 | NAD-dependent protein deacetylase Sir2p homolog; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily. | Nicotinamide mononucleotide adenylyltransferase. | 0.957 |
cobB | TK0134 | TK0685 | TK0134 | NAD-dependent protein deacetylase Sir2p homolog; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily. | Probable acetylpolyamine aminohydrolase, histon deacetylase family. | 0.811 |
cobB | TK0686 | TK0685 | TK0686 | NAD-dependent protein deacetylase Sir2p homolog; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily. | Hydrolase, HAD superfamily. | 0.752 |