STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gdhAGlutamate dehydrogenase. (421 aa)    
Predicted Functional Partners:
TK1094
Alanine aminotransferase.
  
 
 0.969
glnA
Glutamine synthetase; Carries out the ATP-dependent synthesis of glutamine from ammonium nitrogen and glutamate. Exhibits both L-gamma- glutamylhydroxamate synthetase and gamma-glutamyltransferase activities when using hydroxylamine as substrate; in fact, the enzyme possesses low biosynthetic activity, suggesting that the reaction is biased towards the degradation of glutamine under ammonia-rich conditions. Might play some role in ammonia assimilation under ammonia-starvation conditions. Can also use GTP instead of ATP in the synthetase reaction, but not CTP or UTP.
  
 
 0.956
TK0672
Glutamate synthase beta chain-related oxidoreductase.
  
 0.949
TK1325
ferredoxin:NADP oxidoreductase, alpha subunit.
  
 0.949
TK1684
ferredoxin:NADP oxidoreductase, alpha subunit.
  
 0.949
TK2074
Glutamate synthase beta chain-related oxidoreductase.
  
 0.949
cobB
NAD-dependent protein deacetylase Sir2p homolog; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily.
  
 0.932
TK2268
Aspartate aminotransferase.
  
 
 0.920
aspC
Probable aromatic aminotransferase; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
  
 
 0.919
cpkA
Carbamate kinase-like carbamoyl phosphate synthetase.
     
 0.914
Your Current Organism:
Thermococcus kodakarensis
NCBI taxonomy Id: 69014
Other names: Pyrococcus sp. (strain KOD1), Pyrococcus sp. KOD1, T. kodakarensis KOD1, Thermococcus kodakaraensis KOD1, Thermococcus kodakarensis KOD1, Thermococcus kodakarensis str. KOD1, Thermococcus kodakarensis strain KOD1
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