STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TK1686Hypothetical protein, conserved, DUF137 family; Catalyzes the condensation of (R)-4-phosphopantoate and beta- alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway. Cannot use (R)- pantoate as substrate and thus does not display pantothenate synthetase (PS) activity. Displays strict specificity for its natural substrates, 4-phosphopantoate, ATP and beta-alanine. (261 aa)    
Predicted Functional Partners:
TK2141
GHMP kinase; Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway. Displays broad nucleotide specificity and utilizes ATP, GTP, UTP, and CTP with comparable catalytic efficiencies.
 
  
 0.995
coaBC
Phosphopantothenoylcysteine synthetase/decarboxylase; Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'- phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family.
 
  
 0.985
mfnA
Glutamate decarboxylase; Catalyzes the decarboxylation of L-aspartate to produce beta- alanine. In vitro, can also catalyzes the decarboxylation of L- glutamate to produce 4-aminobutanoate, but this activity does not seem necessary in vivo. Shows much higher activity with L-aspartate than with L-glutamate. Does not decarboxylate L-tyrosine. Belongs to the group II decarboxylase family. MfnA subfamily.
 
  
 0.980
TK1211
Aminotransferase, class III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
     
  0.900
TK2101
Aminotransferase, class III; L-ornithine aminotransferase involved in L-proline biosynthesis. Also shows high activity toward L-lysine. 2-oxoglutarate is the best amino acceptor, but 2-oxoadipate also leads to moderate activity; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
     
  0.900
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
 
   
 0.798
TK1968
2-dehydropantoate 2-reductase; Catalyzes the NAD(P)H-dependent reduction of ketopantoate into pantoic acid. Prefers NADH rather than NADPH as the electron donor.
     
 0.759
TK1335
Hypothetical protein, conserved, DUF54 family; Belongs to the UPF0201 family.
 
   
 0.617
TK1685
ferredoxin:NADP oxidoreductase, beta subunit.
       0.582
nusA
Transcription termination-antitermination factor, NusA homolog; Participates in transcription termination. Belongs to the NusA family.
 
     0.522
Your Current Organism:
Thermococcus kodakarensis
NCBI taxonomy Id: 69014
Other names: Pyrococcus sp. (strain KOD1), Pyrococcus sp. KOD1, T. kodakarensis KOD1, Thermococcus kodakaraensis KOD1, Thermococcus kodakarensis KOD1, Thermococcus kodakarensis str. KOD1, Thermococcus kodakarensis strain KOD1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.