node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
TK1900 | cdc6 | TK1900 | TK1901 | Calcium-gated potassium channel protein. | Cell division control protein 6 homolog; Involved in regulation of DNA replication. | 0.637 |
TK1900 | nucS | TK1900 | TK1898 | Calcium-gated potassium channel protein. | Hypothetical protein, conserved, DUF91 family; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family. | 0.589 |
TK1900 | radA | TK1900 | TK1899 | Calcium-gated potassium channel protein. | RadA/Rad51 recombinase; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules (By similarity). | 0.826 |
TK1961 | cdc6 | TK1961 | TK1901 | Replication factor A complex, RPA41 subunit. | Cell division control protein 6 homolog; Involved in regulation of DNA replication. | 0.768 |
TK1961 | fen | TK1961 | TK1281 | Replication factor A complex, RPA41 subunit. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.717 |
TK1961 | pcn1 | TK1961 | TK0535 | Replication factor A complex, RPA41 subunit. | DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.911 |
TK1961 | pol | TK1961 | TK0001 | Replication factor A complex, RPA41 subunit. | DNA-directed DNA polymerase, family B; Intein encoded endonucleases are thought to mediate intein mobility by site-specific recombination initiated by endonuclease cleavage at the 'homing site' in gene that lack the intein. PI-PkoI recognizes 5'-GATTTAGATCCCTGTACC-3' and PI-PkoII recognizes 5'- CAGCTACTACGGTTAC-3'. | 0.805 |
TK1961 | radA | TK1961 | TK1899 | Replication factor A complex, RPA41 subunit. | RadA/Rad51 recombinase; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules (By similarity). | 0.905 |
cdc6 | TK1900 | TK1901 | TK1900 | Cell division control protein 6 homolog; Involved in regulation of DNA replication. | Calcium-gated potassium channel protein. | 0.637 |
cdc6 | TK1961 | TK1901 | TK1961 | Cell division control protein 6 homolog; Involved in regulation of DNA replication. | Replication factor A complex, RPA41 subunit. | 0.768 |
cdc6 | fen | TK1901 | TK1281 | Cell division control protein 6 homolog; Involved in regulation of DNA replication. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.832 |
cdc6 | pcn1 | TK1901 | TK0535 | Cell division control protein 6 homolog; Involved in regulation of DNA replication. | DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.647 |
cdc6 | pol | TK1901 | TK0001 | Cell division control protein 6 homolog; Involved in regulation of DNA replication. | DNA-directed DNA polymerase, family B; Intein encoded endonucleases are thought to mediate intein mobility by site-specific recombination initiated by endonuclease cleavage at the 'homing site' in gene that lack the intein. PI-PkoI recognizes 5'-GATTTAGATCCCTGTACC-3' and PI-PkoII recognizes 5'- CAGCTACTACGGTTAC-3'. | 0.945 |
cdc6 | radA | TK1901 | TK1899 | Cell division control protein 6 homolog; Involved in regulation of DNA replication. | RadA/Rad51 recombinase; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules (By similarity). | 0.903 |
cdc6 | tbp | TK1901 | TK0132 | Cell division control protein 6 homolog; Involved in regulation of DNA replication. | Transcription initiation factor TFIID; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. | 0.412 |
fen | TK1961 | TK1281 | TK1961 | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | Replication factor A complex, RPA41 subunit. | 0.717 |
fen | cdc6 | TK1281 | TK1901 | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | Cell division control protein 6 homolog; Involved in regulation of DNA replication. | 0.832 |
fen | hjc | TK1281 | TK1175 | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | Archaeal type Holliday junction resolvase; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products. | 0.825 |
fen | nucS | TK1281 | TK1898 | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | Hypothetical protein, conserved, DUF91 family; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family. | 0.747 |
fen | pcn1 | TK1281 | TK0535 | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.991 |