STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (226 aa)    
Predicted Functional Partners:
gap
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating).
 
 0.999
pgk
3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.
 
 
 0.994
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
  
 
 0.985
fbp
Thermophile-specific fructose-1,6-bisphosphatase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). Does not display hydrolase activity against fructose 2,6-bisphosphate, fructose 6-phosphate, fructose 1- phosphate, glucose 6-phosphate, and glucose 1-phosphate. Exhibits only negligible activity on inositol-1- phosphate (IMP). Is essential for the growth of T.kodakaraensis under gluconeogen [...]
    
 0.977
fba
DhnA-type fructose-1,6-bisphosphate aldolase; Belongs to the DeoC/FbaB aldolase family.
 
 
 0.967
TK0705
NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (non-phosphorylating); Belongs to the aldehyde dehydrogenase family.
  
 0.963
TK2132
Fuculose-1-phosphate aldolase.
  
 
 0.962
TK1497
Enolase-related protein.
 
 
 0.935
deoC
Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate. Could be involved in pentose biosynthesis. Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
  
 0.923
TK2163
Tungsten-containing glyceraldehyde-3-phosphate:ferredoxin oxidoreductase.
    
  0.911
Your Current Organism:
Thermococcus kodakarensis
NCBI taxonomy Id: 69014
Other names: Pyrococcus sp. (strain KOD1), Pyrococcus sp. KOD1, T. kodakarensis KOD1, Thermococcus kodakaraensis KOD1, Thermococcus kodakarensis KOD1, Thermococcus kodakarensis str. KOD1, Thermococcus kodakarensis strain KOD1
Server load: low (28%) [HD]