node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
TK1212 | pyrB | TK1212 | TK2196 | Xanthine/uracilpermease. | Aspartate carbamoyltransferase, catalytic subunit. | 0.987 |
TK1212 | pyrC | TK1212 | TK1805 | Xanthine/uracilpermease. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.978 |
TK1212 | pyrD | TK1212 | TK2260 | Xanthine/uracilpermease. | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. | 0.821 |
TK1212 | pyrE | TK1212 | TK2138 | Xanthine/uracilpermease. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.959 |
TK1212 | pyrF | TK1212 | TK2276 | Xanthine/uracilpermease. | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.965 |
TK1212 | upp | TK1212 | TK1287 | Xanthine/uracilpermease. | Uracilphosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.818 |
pyrB | TK1212 | TK2196 | TK1212 | Aspartate carbamoyltransferase, catalytic subunit. | Xanthine/uracilpermease. | 0.987 |
pyrB | pyrC | TK2196 | TK1805 | Aspartate carbamoyltransferase, catalytic subunit. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.999 |
pyrB | pyrD | TK2196 | TK2260 | Aspartate carbamoyltransferase, catalytic subunit. | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. | 0.996 |
pyrB | pyrE | TK2196 | TK2138 | Aspartate carbamoyltransferase, catalytic subunit. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.990 |
pyrB | pyrF | TK2196 | TK2276 | Aspartate carbamoyltransferase, catalytic subunit. | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.989 |
pyrB | pyrH | TK2196 | TK0305 | Aspartate carbamoyltransferase, catalytic subunit. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.607 |
pyrB | pyrI | TK2196 | TK2195 | Aspartate carbamoyltransferase, catalytic subunit. | Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. | 0.999 |
pyrB | surE | TK2196 | TK1137 | Aspartate carbamoyltransferase, catalytic subunit. | Acid phosphatase SurE homolog; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.510 |
pyrB | upp | TK2196 | TK1287 | Aspartate carbamoyltransferase, catalytic subunit. | Uracilphosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.908 |
pyrC | TK1212 | TK1805 | TK1212 | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | Xanthine/uracilpermease. | 0.978 |
pyrC | pyrB | TK1805 | TK2196 | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | Aspartate carbamoyltransferase, catalytic subunit. | 0.999 |
pyrC | pyrD | TK1805 | TK2260 | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. | 0.999 |
pyrC | pyrE | TK1805 | TK2138 | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.991 |
pyrC | pyrF | TK1805 | TK2276 | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.987 |