STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (191 aa)    
Predicted Functional Partners:
ADQ80476.1
COGs: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; InterPro IPR000836: IPR005904; KEGG: bfs:BF1031 putative hypoxanthine guanine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; PRIAM: Hypoxanthine phosphoribosyltransferase; SPTR: Putative uncharacterized protein; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain; TIGRFAM: hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
 
  
 0.970
secY
Protein translocase subunit secY/sec61 alpha; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
 
  
 0.954
ADQ80328.1
COGs: COG0015 Adenylosuccinate lyase; InterPro IPR000362: IPR013539: IPR004769: IPR020557; KEGG: bvu:BVU_1626 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase domain-containing protein; fumarate lyase; PRIAM: Adenylosuccinate lyase; SPTR: Putative uncharacterized protein; TIGRFAM: adenylosuccinate lyase; PFAM: Lyase; Adenylosuccinate lyase C-terminal; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
   
 0.945
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
  
 
 0.940
ADQ80522.1
COGs: COG0105 Nucleoside diphosphate kinase; InterPro IPR001564; KEGG: pdi:BDI_1575 nucleoside diphosphate kinase; PFAM: nucleoside diphosphate kinase; PRIAM: Nucleoside-diphosphate kinase; SMART: nucleoside diphosphate kinase; SPTR: Nucleoside diphosphate kinase; PFAM: Nucleoside diphosphate kinase; Belongs to the NDK family.
  
 0.937
ADQ80381.1
COGs: COG0469 Pyruvate kinase; InterPro IPR015793: IPR015794: IPR001697: IPR018209; KEGG: bth:BT_2841 pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; PRIAM: Pyruvate kinase; SPTR: Pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family.
 
 0.934
ADQ78766.1
Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
    
 0.921
surE
5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
     
 0.920
ADQ79979.1
Metallophosphoesterase; COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterPro IPR004843: IPR006179: IPR006146; KEGG: fps:FP1833 5'-nucleotidase; PFAM: metallophosphoesterase; SPTR: Possible secreted 5'-nucleotidase; PFAM: Calcineurin-like phosphoesterase.
    
 0.902
ADQ78886.1
AMP nucleosidase; COGs: COG0775 Nucleoside phosphorylase; InterPro IPR000845: IPR010944; KEGG: bfs:BF2479 AMP nucleosidase; PFAM: purine or other phosphorylase family 1; SPTR: Putative AMP nucleosidase; TIGRFAM: AMP nucleosidase; manually curated; PFAM: Phosphorylase superfamily; TIGRFAM: AMP nucleosidase, putative.
     
  0.900
Your Current Organism:
Paludibacter propionicigenes
NCBI taxonomy Id: 694427
Other names: P. propionicigenes WB4, Paludibacter propionicigenes CCUG 53888, Paludibacter propionicigenes DSM 17365, Paludibacter propionicigenes JCM 13257, Paludibacter propionicigenes WB4, Paludibacter propionicigenes str. WB4, Paludibacter propionicigenes strain WB4
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.