STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nep1Suppressor Mra1 family protein; Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. (240 aa)    
Predicted Functional Partners:
AEM38640.1
PFAM: KH domain; TIGRFAM: arCOG04150 universal archaeal KH domain protein; COGs: COG1444 P-loop ATPase fused to an acetyltransferase; InterPro IPR000182; KEGG: hbu:Hbut_1153 P-loop ATPase; PFAM: GCN5-related N-acetyltransferase; SPTR: P-loop ATPase.
 
 0.933
rps4
Ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
   
  0.907
AEM39664.1
Pre-mRNA processing ribonucleoprotein, binding domain protein; PFAM: Putative snoRNA binding domain; NOSIC (NUC001) domain; KEGG: tag:Tagg_0901 MarR family transcriptional regulator; SPTR: Transcriptional regulator, MarR family.
  
 
 0.899
csl4
Hypothetical protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.
 
  0.896
rps19e
Ribosomal protein S19e; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family.
  
 
 0.892
rps6e
PFAM: Ribosomal protein S6e; Belongs to the eukaryotic ribosomal protein eS6 family.
   
  0.882
rps11
Ribosomal protein S11P; Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family.
   
 0.873
rtcA
RNA 3'-phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
  
 
 0.868
rrp4
KH domain protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.
  
  0.841
rps3ae
PFAM: Ribosomal S3Ae family; KEGG: hbu:Hbut_0167 hypothetical protein; SPTR: Putative uncharacterized protein; Belongs to the eukaryotic ribosomal protein eS1 family.
  
  0.826
Your Current Organism:
Pyrolobus fumarii
NCBI taxonomy Id: 694429
Other names: P. fumarii 1A, Pyrolobus fumarii 1A, Pyrolobus fumarii DSM 11204
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.