STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
B7PL03_IXOSC2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (453 aa)    
Predicted Functional Partners:
B7PR76_IXOSC
Branched chain alpha-keto acid dehydrogenase, putative (Fragment).
 0.999
B7PZE3_IXOSC
Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
 0.996
B7PEH7_IXOSC
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.
 
 0.992
B7P5K8_IXOSC
Branched-chain amino acid aminotransferase, putative.
  
 
 0.984
B7P6B5_IXOSC
Dihydrolipoyl dehydrogenase.
  
 
 0.969
B7PWE7_IXOSC
Dihydrolipoyl dehydrogenase.
  
 
 0.969
B7PL04_IXOSC
2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).
  
  
 
0.904
B7Q1W9_IXOSC
Dihydrolipoamide acetyltransferase, putative (Fragment).
  
 0.889
B7P465_IXOSC
Dihydrolipoamide dehydrogenase, putative (Fragment).
  
 
 0.861
B7Q0D5_IXOSC
Pyruvate kinase; Belongs to the pyruvate kinase family.
  
 
 0.853
Your Current Organism:
Ixodes scapularis
NCBI taxonomy Id: 6945
Other names: I. scapularis, Ixodes dammini, Ixodes sp. DNAS-303-249710, black-legged tick, blacklegged tick, deer tick, shoulder tick
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.