STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
B7PL05_IXOSCCyclin k, putative; Belongs to the cyclin family. (445 aa)    
Predicted Functional Partners:
B7PB82_IXOSC
Cdk activating kinase, putative; Belongs to the cyclin family.
     
 0.941
B7Q3M6_IXOSC
Protein kinase, putative; Belongs to the protein kinase superfamily.
     
 0.936
B7Q4L6_IXOSC
Transcription elongation factor SPT4; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II; Belongs to the SPT4 family.
    
 0.930
B7PNC8_IXOSC
Transcription elongation factor SPT5.
    
 0.915
B7Q1H7_IXOSC
Negative elongation factor E, putative (Fragment).
    
 0.898
B7PDX2_IXOSC
Uncharacterized protein.
    
 0.877
B7Q220_IXOSC
FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]
   
 
 0.854
B7Q3X0_IXOSC
CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.
     
 0.849
B7Q633_IXOSC
Proline-rich protein, putative.
   
 0.847
B7PNZ8_IXOSC
Protein kinase, putative (Fragment); Belongs to the protein kinase superfamily.
    
 0.846
Your Current Organism:
Ixodes scapularis
NCBI taxonomy Id: 6945
Other names: I. scapularis, Ixodes dammini, Ixodes sp. DNAS-303-249710, black-legged tick, blacklegged tick, deer tick, shoulder tick
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.