STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
B7PWN0_IXOSCUncharacterized protein. (52 aa)    
Predicted Functional Partners:
B7Q2A2_IXOSC
Zinc finger protein, putative.
   
 
 0.906
B7QNJ1_IXOSC
RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
    
 
 0.839
B7PEW4_IXOSC
Histone H2A; Belongs to the histone H2A family.
   
 
 0.831
B7PYR8_IXOSC
RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
    
 
 0.831
B7QDJ9_IXOSC
EP400_N domain-containing protein.
    
 
 0.822
B7Q529_IXOSC
YL1 nuclear protein Cterminal domain-containing protein.
    
 
 0.787
B7Q0X9_IXOSC
DNA methyltransferase 1-associated protein-1, putative (Fragment).
    
 
 0.726
B7Q3R9_IXOSC
Transcription initiation factor IIF, auxiliary subunit, putative.
   
 
 0.682
Q4PM69_IXOSC
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
   
   0.558
B7P5Z5_IXOSC
Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.
    
 
 0.412
Your Current Organism:
Ixodes scapularis
NCBI taxonomy Id: 6945
Other names: I. scapularis, Ixodes dammini, Ixodes sp. DNAS-303-249710, black-legged tick, blacklegged tick, deer tick, shoulder tick
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.