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folD protein (Midichloria mitochondrii) - STRING interaction network
"folD" - Methylenetetrahydrofolate dehydrogenase in Midichloria mitochondrii
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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folDMethylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (292 aa)    
Predicted Functional Partners:
glyA
Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (423 aa)
   
  0.992
midi_00467
5-formyltetrahydrofolate cyclo-ligase (202 aa)
   
  0.978
fmt
methionyl-tRNA formyltransferase; Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by- (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (313 aa)
 
 
  0.960
thyX
FAD-dependent thymidylate synthase; Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (313 aa)
       
  0.908
midi_00573
ferredoxin--NADP+ reductase (333 aa)
   
   
  0.875
rbn
Ribonuclease BN (290 aa)
              0.864
cysS
cysteinyl-tRNA synthetase (458 aa)
   
   
  0.644
rplP
Ribosomal protein S10; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (138 aa)
     
 
  0.643
rplJ
Ribosomal protein L10 (100 aa)
     
 
  0.627
midi_00574
Hypothetical protein (480 aa)
              0.607
Your Current Organism:
Midichloria mitochondrii
NCBI taxonomy Id: 696127
Other names: C. Midichloria, C. Midichloria mitochondrii, C. Midichloria mitochondrii IricVA, Candidatus Midichloria, Candidatus Midichloria mitochondrii, Candidatus Midichloria mitochondrii IricVA, Candidatus Midichloria mitochondrii str. IricVA, Candidatus Midichloria mitochondrii strain IricVA, Ixodes ricinus endosymbiont, Ixodes ricinus endosymbiont 1 (IricES1), Midichloria, Midichloria mitochondrii, Midichloria mitochondrii IricVA, endosymbiont of Ixodes ricinus
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