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leuA protein (Methylobacter tundripaludum) - STRING interaction network
"leuA" - 2-isopropylmalate synthase in Methylobacter tundripaludum
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second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily (514 aa)    
Predicted Functional Partners:
leuC
3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate; Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily (472 aa)
 
  0.999
leuD
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate; Belongs to the LeuD family. LeuD type 1 subfamily (203 aa)
 
 
  0.998
Mettu_0785
PFAM- Dihydroxy-acid/6-phosphogluconate dehydratase; TIGRFAM- Dihydroxy-acid dehydratase; HAMAP- Dihydroxy-acid dehydratase; KEGG- mca-MCA2082 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family (562 aa)
 
 
  0.990
Mettu_3986
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (368 aa)
 
  0.988
Mettu_2231
PFAM- Dihydroxy-acid/6-phosphogluconate dehydratase; TIGRFAM- Dihydroxy-acid dehydratase; HAMAP- Dihydroxy-acid dehydratase; KEGG- mmb-Mmol_0396 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family (617 aa)
 
 
  0.987
Mettu_2397
TIGRFAM- Acetolactate synthase, large subunit, biosynthetic; KEGG- mca-MCA2270 acetolactate synthase, large subunit, biosynthetic type; PFAM- Thiamine pyrophosphate enzyme, N-terminal TPP binding region; Thiamine pyrophosphate enzyme, central region; Thiamine pyrophosphate enzyme, C-terminal TPP-binding (578 aa)
 
 
  0.953
ilvE
Branched-chain-amino-acid aminotransferase; Acts on leucine, isoleucine and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family (308 aa)
  0.949
Mettu_3480
Pyruvate-flavodoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (1212 aa)
       
  0.936
Mettu_2398
KEGG- mca-MCA2271 acetolactate synthase, small subunit; TIGRFAM- Acetolactate synthase, small subunit; PFAM- Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT (163 aa)
 
 
  0.891
Mettu_0443
Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family (803 aa)
   
 
  0.886
Your Current Organism:
Methylobacter tundripaludum
NCBI taxonomy Id: 697282
Other names: M. tundripaludum SV96, Methylobacter sp. SV96, Methylobacter tundripaludum, Methylobacter tundripaludum DSM 17260, Methylobacter tundripaludum SV96, Methylobacter tundripaludum str. SV96, Methylobacter tundripaludum strain SV96
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