| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Mettu_0161 | Mettu_0162 | Mettu_0161 | Mettu_0162 | Agmatine deiminase | Recombination protein N ; May be involved in recombinational repair of damaged DNA | 0.859 |
| Mettu_0161 | nadK | Mettu_0161 | Mettu_0163 | Agmatine deiminase | ATP-dependent NAD kinase ; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2’-hydroxyl of the adenosine moiety of NAD to yield NADP | 0.859 |
| Mettu_0162 | Mettu_0161 | Mettu_0162 | Mettu_0161 | Recombination protein N ; May be involved in recombinational repair of damaged DNA | Agmatine deiminase | 0.859 |
| Mettu_0162 | lexA | Mettu_0162 | Mettu_1376 | Recombination protein N ; May be involved in recombinational repair of damaged DNA | LexA repressor ; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair | 0.855 |
| Mettu_0162 | mfd | Mettu_0162 | Mettu_0674 | Recombination protein N ; May be involved in recombinational repair of damaged DNA | Transcription-repair-coupling factor ; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site | 0.855 |
| Mettu_0162 | nadK | Mettu_0162 | Mettu_0163 | Recombination protein N ; May be involved in recombinational repair of damaged DNA | ATP-dependent NAD kinase ; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2’-hydroxyl of the adenosine moiety of NAD to yield NADP | 0.900 |
| Mettu_0162 | recA | Mettu_0162 | Mettu_4087 | Recombination protein N ; May be involved in recombinational repair of damaged DNA | Recombinase A ; Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage | 0.925 |
| Mettu_0162 | recF | Mettu_0162 | Mettu_1954 | Recombination protein N ; May be involved in recombinational repair of damaged DNA | DNA replication and repair protein RecF ; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP | 0.932 |
| Mettu_0162 | recG | Mettu_0162 | Mettu_2546 | Recombination protein N ; May be involved in recombinational repair of damaged DNA | ATP-dependent DNA helicase RecG ; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3’- to 5’- polarity. Unwinds branched duplex DNA (Y-DNA) | 0.885 |
| Mettu_0162 | recR | Mettu_0162 | Mettu_3091 | Recombination protein N ; May be involved in recombinational repair of damaged DNA | Recombination protein RecR ; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO | 0.891 |
| Mettu_0162 | ruvA | Mettu_0162 | Mettu_3550 | Recombination protein N ; May be involved in recombinational repair of damaged DNA | Holliday junction ATP-dependent DNA helicase RuvA ; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB | 0.890 |
| Mettu_0162 | uvrA | Mettu_0162 | Mettu_4250 | Recombination protein N ; May be involved in recombinational repair of damaged DNA | Excinuclease ABC subunit A ; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate | 0.881 |
| lexA | Mettu_0162 | Mettu_1376 | Mettu_0162 | LexA repressor ; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair | Recombination protein N ; May be involved in recombinational repair of damaged DNA | 0.855 |
| lexA | mfd | Mettu_1376 | Mettu_0674 | LexA repressor ; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair | Transcription-repair-coupling factor ; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site | 0.549 |
| lexA | recA | Mettu_1376 | Mettu_4087 | LexA repressor ; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair | Recombinase A ; Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage | 0.982 |
| lexA | recF | Mettu_1376 | Mettu_1954 | LexA repressor ; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair | DNA replication and repair protein RecF ; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP | 0.719 |
| lexA | recG | Mettu_1376 | Mettu_2546 | LexA repressor ; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair | ATP-dependent DNA helicase RecG ; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3’- to 5’- polarity. Unwinds branched duplex DNA (Y-DNA) | 0.604 |
| lexA | recR | Mettu_1376 | Mettu_3091 | LexA repressor ; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair | Recombination protein RecR ; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO | 0.622 |
| lexA | ruvA | Mettu_1376 | Mettu_3550 | LexA repressor ; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair | Holliday junction ATP-dependent DNA helicase RuvA ; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB | 0.719 |
| lexA | uvrA | Mettu_1376 | Mettu_4250 | LexA repressor ; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair | Excinuclease ABC subunit A ; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate | 0.818 |
