| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Mettu_0161 | Mettu_0162 | Mettu_0161 | Mettu_0162 | Agmatine deiminase; KEGG- mca-MCA1861 hypothetical protein; PFAM- Peptidyl-arginine deiminase, Porphyromonas-type; Belongs to the agmatine deiminase family | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA | 0.857 |
| Mettu_0161 | nadK | Mettu_0161 | Mettu_0163 | Agmatine deiminase; KEGG- mca-MCA1861 hypothetical protein; PFAM- Peptidyl-arginine deiminase, Porphyromonas-type; Belongs to the agmatine deiminase family | NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2’-hydroxyl of the adenosine moiety of NAD to yield NADP | 0.856 |
| Mettu_0162 | Mettu_0161 | Mettu_0162 | Mettu_0161 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA | Agmatine deiminase; KEGG- mca-MCA1861 hypothetical protein; PFAM- Peptidyl-arginine deiminase, Porphyromonas-type; Belongs to the agmatine deiminase family | 0.857 |
| Mettu_0162 | mfd | Mettu_0162 | Mettu_0674 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA | Transcription-repair-coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site | 0.848 |
| Mettu_0162 | nadK | Mettu_0162 | Mettu_0163 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA | NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2’-hydroxyl of the adenosine moiety of NAD to yield NADP | 0.907 |
| Mettu_0162 | polA | Mettu_0162 | Mettu_2187 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity | 0.787 |
| Mettu_0162 | recA | Mettu_0162 | Mettu_4087 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA | Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage | 0.940 |
| Mettu_0162 | recF | Mettu_0162 | Mettu_1954 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA | DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP | 0.839 |
| Mettu_0162 | recG | Mettu_0162 | Mettu_2546 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA | ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3’- to 5’- polarity. Unwinds branched duplex DNA (Y-DNA) | 0.841 |
| Mettu_0162 | recR | Mettu_0162 | Mettu_3091 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA | Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO | 0.848 |
| Mettu_0162 | ruvA | Mettu_0162 | Mettu_3550 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA | Holliday junction ATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB | 0.825 |
| Mettu_0162 | ruvB | Mettu_0162 | Mettu_3549 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA | Holliday junction ATP-dependent DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing | 0.874 |
| mfd | Mettu_0162 | Mettu_0674 | Mettu_0162 | Transcription-repair-coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA | 0.848 |
| mfd | polA | Mettu_0674 | Mettu_2187 | Transcription-repair-coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity | 0.827 |
| mfd | recA | Mettu_0674 | Mettu_4087 | Transcription-repair-coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site | Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage | 0.635 |
| mfd | recF | Mettu_0674 | Mettu_1954 | Transcription-repair-coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site | DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP | 0.566 |
| mfd | recG | Mettu_0674 | Mettu_2546 | Transcription-repair-coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site | ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3’- to 5’- polarity. Unwinds branched duplex DNA (Y-DNA) | 0.454 |
| mfd | recR | Mettu_0674 | Mettu_3091 | Transcription-repair-coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site | Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO | 0.677 |
| mfd | ruvA | Mettu_0674 | Mettu_3550 | Transcription-repair-coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site | Holliday junction ATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB | 0.755 |
| mfd | ruvB | Mettu_0674 | Mettu_3549 | Transcription-repair-coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site | Holliday junction ATP-dependent DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing | 0.738 |
