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fpg protein (Methylobacter tundripaludum) - STRING interaction network
"fpg" - Formamidopyrimidine-DNA glycosylase in Methylobacter tundripaludum
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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fpgFormamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3’- and 5’-phosphates (271 aa)    
Predicted Functional Partners:
coaE
Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3’-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family (200 aa)
 
   
  0.934
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity (930 aa)
   
   
  0.890
ybeY
Endoribonuclease YbeY; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3’ terminus of the 16S rRNA (153 aa)
   
 
  0.789
coaD
Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4’- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate; Belongs to the bacterial CoaD family (161 aa)
       
  0.738
Mettu_1918
TIGRFAM- A/G-specific adenine glycosylase MutY, bacterial form; PFAM- HhH-GPD domain; Endonuclease III-like, iron-sulphur cluster loop motif; KEGG- tgr-Tgr7_2945 A/G-specific DNA-adenine glycosylase; SMART- HhH-GPD domain (349 aa)
 
 
  0.732
purL
Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (1289 aa)
 
   
  0.728
Mettu_0443
Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family (803 aa)
         
  0.674
Mettu_3001
KEGG- mca-MCA2627 DNA internalization-related competence protein ComEC/Rec2; TIGRFAM- Competence protein ComEC/Rec2; ComEC/Rec2-related protein; PFAM- ComEC/Rec2-related protein (777 aa)
 
     
  0.656
guaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP (528 aa)
         
  0.648
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3’ to the AP site by a beta-elimination, leaving a 3’-terminal unsaturated sugar and a product with a terminal 5’-phosphate (241 aa)
   
   
  0.629
Your Current Organism:
Methylobacter tundripaludum
NCBI taxonomy Id: 697282
Other names: M. tundripaludum SV96, Methylobacter sp. SV96, Methylobacter tundripaludum, Methylobacter tundripaludum DSM 17260, Methylobacter tundripaludum SV96, Methylobacter tundripaludum str. SV96, Methylobacter tundripaludum strain SV96
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