node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mettu_0078 | Mettu_4306 | Mettu_0078 | Mettu_4306 | KEGG- nhl-Nhal_3853 mutator MutT protein; TIGRFAM- Mutator MutT protein; PFAM- Thiamine monophosphate synthase; NUDIX hydrolase domain | KEGG- tgr-Tgr7_2419 phosphomethylpyrimidine kinase; PFAM- Phosphomethylpyrimidine kinase type-1 | 0.945 |
Mettu_0078 | adk | Mettu_0078 | Mettu_0091 | KEGG- nhl-Nhal_3853 mutator MutT protein; TIGRFAM- Mutator MutT protein; PFAM- Thiamine monophosphate synthase; NUDIX hydrolase domain | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family | 0.457 |
Mettu_0078 | purL | Mettu_0078 | Mettu_3166 | KEGG- nhl-Nhal_3853 mutator MutT protein; TIGRFAM- Mutator MutT protein; PFAM- Thiamine monophosphate synthase; NUDIX hydrolase domain | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate | 0.634 |
Mettu_0078 | ribB | Mettu_0078 | Mettu_0903 | KEGG- nhl-Nhal_3853 mutator MutT protein; TIGRFAM- Mutator MutT protein; PFAM- Thiamine monophosphate synthase; NUDIX hydrolase domain | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family | 0.916 |
Mettu_0078 | thiC | Mettu_0078 | Mettu_2490 | KEGG- nhl-Nhal_3853 mutator MutT protein; TIGRFAM- Mutator MutT protein; PFAM- Thiamine monophosphate synthase; NUDIX hydrolase domain | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction | 0.882 |
Mettu_0078 | thiE | Mettu_0078 | Mettu_4305 | KEGG- nhl-Nhal_3853 mutator MutT protein; TIGRFAM- Mutator MutT protein; PFAM- Thiamine monophosphate synthase; NUDIX hydrolase domain | Thiamine-phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP); Belongs to the thiamine-phosphate synthase family | 0.568 |
Mettu_0078 | thiL | Mettu_0078 | Mettu_0906 | KEGG- nhl-Nhal_3853 mutator MutT protein; TIGRFAM- Mutator MutT protein; PFAM- Thiamine monophosphate synthase; NUDIX hydrolase domain | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family | 0.841 |
Mettu_0907 | nusB | Mettu_0907 | Mettu_0905 | Phosphatidylglycerophosphatase A; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) | Transcription antitermination protein NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons | 0.847 |
Mettu_0907 | ribB | Mettu_0907 | Mettu_0903 | Phosphatidylglycerophosphatase A; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family | 0.668 |
Mettu_0907 | ribH | Mettu_0907 | Mettu_0904 | Phosphatidylglycerophosphatase A; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family | 0.819 |
Mettu_0907 | thiL | Mettu_0907 | Mettu_0906 | Phosphatidylglycerophosphatase A; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family | 0.911 |
Mettu_4306 | Mettu_0078 | Mettu_4306 | Mettu_0078 | KEGG- tgr-Tgr7_2419 phosphomethylpyrimidine kinase; PFAM- Phosphomethylpyrimidine kinase type-1 | KEGG- nhl-Nhal_3853 mutator MutT protein; TIGRFAM- Mutator MutT protein; PFAM- Thiamine monophosphate synthase; NUDIX hydrolase domain | 0.945 |
Mettu_4306 | purL | Mettu_4306 | Mettu_3166 | KEGG- tgr-Tgr7_2419 phosphomethylpyrimidine kinase; PFAM- Phosphomethylpyrimidine kinase type-1 | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate | 0.538 |
Mettu_4306 | ribB | Mettu_4306 | Mettu_0903 | KEGG- tgr-Tgr7_2419 phosphomethylpyrimidine kinase; PFAM- Phosphomethylpyrimidine kinase type-1 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family | 0.556 |
Mettu_4306 | thiC | Mettu_4306 | Mettu_2490 | KEGG- tgr-Tgr7_2419 phosphomethylpyrimidine kinase; PFAM- Phosphomethylpyrimidine kinase type-1 | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction | 0.999 |
Mettu_4306 | thiE | Mettu_4306 | Mettu_4305 | KEGG- tgr-Tgr7_2419 phosphomethylpyrimidine kinase; PFAM- Phosphomethylpyrimidine kinase type-1 | Thiamine-phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP); Belongs to the thiamine-phosphate synthase family | 0.999 |
Mettu_4306 | thiL | Mettu_4306 | Mettu_0906 | KEGG- tgr-Tgr7_2419 phosphomethylpyrimidine kinase; PFAM- Phosphomethylpyrimidine kinase type-1 | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family | 0.932 |
adk | Mettu_0078 | Mettu_0091 | Mettu_0078 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family | KEGG- nhl-Nhal_3853 mutator MutT protein; TIGRFAM- Mutator MutT protein; PFAM- Thiamine monophosphate synthase; NUDIX hydrolase domain | 0.457 |
adk | nusB | Mettu_0091 | Mettu_0905 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family | Transcription antitermination protein NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons | 0.440 |
adk | purL | Mettu_0091 | Mettu_3166 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate | 0.461 |