node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mettu_0443 | Mettu_1417 | Mettu_0443 | Mettu_1417 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family | KEGG- mca-MCA1406 serine--glyoxylate aminotransferase; PFAM- Aminotransferase, class V/Cysteine desulfurase | 0.860 |
Mettu_0443 | Mettu_1418 | Mettu_0443 | Mettu_1418 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family | Glyoxylate reductase; KEGG- mca-MCA1407 2-hydroxyacid dehydrogenase; PFAM- D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region | 0.913 |
Mettu_0443 | Mettu_2277 | Mettu_0443 | Mettu_2277 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family | PFAM- FAD linked oxidase, N-terminal; FAD-linked oxidase, C-terminal; Cysteine-rich region, CCG; KEGG- acp-A2cp1_3218 FAD linked oxidase domain protein | 0.976 |
Mettu_0443 | Mettu_3554 | Mettu_0443 | Mettu_3554 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family | TIGRFAM- D-3-phosphoglycerate dehydrogenase; KEGG- dol-Dole_2852 D-3-phosphoglycerate dehydrogenase; PFAM- D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; Amino acid-binding ACT | 0.913 |
Mettu_0443 | glyA | Mettu_0443 | Mettu_1433 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | 0.637 |
Mettu_0443 | metG | Mettu_0443 | Mettu_1903 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family | Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily | 0.762 |
Mettu_1417 | Mettu_0443 | Mettu_1417 | Mettu_0443 | KEGG- mca-MCA1406 serine--glyoxylate aminotransferase; PFAM- Aminotransferase, class V/Cysteine desulfurase | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family | 0.860 |
Mettu_1417 | Mettu_1418 | Mettu_1417 | Mettu_1418 | KEGG- mca-MCA1406 serine--glyoxylate aminotransferase; PFAM- Aminotransferase, class V/Cysteine desulfurase | Glyoxylate reductase; KEGG- mca-MCA1407 2-hydroxyacid dehydrogenase; PFAM- D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region | 0.933 |
Mettu_1417 | Mettu_2277 | Mettu_1417 | Mettu_2277 | KEGG- mca-MCA1406 serine--glyoxylate aminotransferase; PFAM- Aminotransferase, class V/Cysteine desulfurase | PFAM- FAD linked oxidase, N-terminal; FAD-linked oxidase, C-terminal; Cysteine-rich region, CCG; KEGG- acp-A2cp1_3218 FAD linked oxidase domain protein | 0.855 |
Mettu_1417 | Mettu_2468 | Mettu_1417 | Mettu_2468 | KEGG- mca-MCA1406 serine--glyoxylate aminotransferase; PFAM- Aminotransferase, class V/Cysteine desulfurase | PFAM- Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; KEGG- mca-MCA0381 carbon-nitrogen family hydrolase | 0.926 |
Mettu_1417 | Mettu_3553 | Mettu_1417 | Mettu_3553 | KEGG- mca-MCA1406 serine--glyoxylate aminotransferase; PFAM- Aminotransferase, class V/Cysteine desulfurase | TIGRFAM- HAD-superfamily hydrolase, subfamily IB, PSPase-like; KEGG- cre-CHLREDRAFT_194322 phosphoserine phosphatase; PFAM- Haloacid dehalogenase-like hydrolase | 0.829 |
Mettu_1417 | Mettu_3554 | Mettu_1417 | Mettu_3554 | KEGG- mca-MCA1406 serine--glyoxylate aminotransferase; PFAM- Aminotransferase, class V/Cysteine desulfurase | TIGRFAM- D-3-phosphoglycerate dehydrogenase; KEGG- dol-Dole_2852 D-3-phosphoglycerate dehydrogenase; PFAM- D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; Amino acid-binding ACT | 0.892 |
Mettu_1417 | gcvP | Mettu_1417 | Mettu_3696 | KEGG- mca-MCA1406 serine--glyoxylate aminotransferase; PFAM- Aminotransferase, class V/Cysteine desulfurase | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family | 0.848 |
Mettu_1417 | glyA | Mettu_1417 | Mettu_1433 | KEGG- mca-MCA1406 serine--glyoxylate aminotransferase; PFAM- Aminotransferase, class V/Cysteine desulfurase | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | 0.840 |
Mettu_1417 | metG | Mettu_1417 | Mettu_1903 | KEGG- mca-MCA1406 serine--glyoxylate aminotransferase; PFAM- Aminotransferase, class V/Cysteine desulfurase | Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily | 0.916 |
Mettu_1417 | metK | Mettu_1417 | Mettu_1619 | KEGG- mca-MCA1406 serine--glyoxylate aminotransferase; PFAM- Aminotransferase, class V/Cysteine desulfurase | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme | 0.951 |
Mettu_1418 | Mettu_0443 | Mettu_1418 | Mettu_0443 | Glyoxylate reductase; KEGG- mca-MCA1407 2-hydroxyacid dehydrogenase; PFAM- D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family | 0.913 |
Mettu_1418 | Mettu_1417 | Mettu_1418 | Mettu_1417 | Glyoxylate reductase; KEGG- mca-MCA1407 2-hydroxyacid dehydrogenase; PFAM- D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region | KEGG- mca-MCA1406 serine--glyoxylate aminotransferase; PFAM- Aminotransferase, class V/Cysteine desulfurase | 0.933 |
Mettu_1418 | Mettu_2277 | Mettu_1418 | Mettu_2277 | Glyoxylate reductase; KEGG- mca-MCA1407 2-hydroxyacid dehydrogenase; PFAM- D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region | PFAM- FAD linked oxidase, N-terminal; FAD-linked oxidase, C-terminal; Cysteine-rich region, CCG; KEGG- acp-A2cp1_3218 FAD linked oxidase domain protein | 0.821 |
Mettu_1418 | Mettu_3553 | Mettu_1418 | Mettu_3553 | Glyoxylate reductase; KEGG- mca-MCA1407 2-hydroxyacid dehydrogenase; PFAM- D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region | TIGRFAM- HAD-superfamily hydrolase, subfamily IB, PSPase-like; KEGG- cre-CHLREDRAFT_194322 phosphoserine phosphatase; PFAM- Haloacid dehalogenase-like hydrolase | 0.645 |