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glyA protein (Methylobacter tundripaludum) - STRING interaction network
"glyA" - Serine hydroxymethyltransferase in Methylobacter tundripaludum
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (417 aa)    
Predicted Functional Partners:
gcvP
Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family (963 aa)
 
 
  0.998
Mettu_3697
TIGRFAM- Glycine cleavage system T protein; KEGG- pau-PA14_33040 glycine cleavage system protein T2; PFAM- Glycine cleavage T-protein, N-terminal; Glycine cleavage T-protein, C-terminal barrel (360 aa)
 
  0.992
Mettu_0892
FolC bifunctional protein; TIGRFAM- Folylpolyglutamate synthetase; KEGG- mca-MCA2492 folylpolyglutamate synthase/dihydrofolate synthase; PFAM- Mur ligase, central; Mur ligase, C-terminal (423 aa)
   
  0.987
purH
Bifunctional purine biosynthesis protein PurH; KEGG- maq-Maqu_3450 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM- AICARFT/IMPCHase bienzyme, formylation region; MGS-like; TIGRFAM- AICARFT/IMPCHase bienzyme; HAMAP- Bifunctional purine biosynthesis protein purH; SMART- AICARFT/IMPCHase bienzyme, formylation region (535 aa)
   
  0.983
Mettu_0846
KEGG- mca-MCA2087 HAD family hydrolase; TIGRFAM- HAD-superfamily hydrolase, subfamily IB, PSPase-like, bacterial; HAD-superfamily hydrolase, subfamily IB, PSPase-like; PFAM- Haloacid dehalogenase-like hydrolase (228 aa)
   
  0.981
fhs
HAMAP- Formate-tetrahydrofolate ligase, FTHFS; KEGG- mca-MCA2219 formate--tetrahydrofolate ligase; PFAM- Formate-tetrahydrofolate ligase, FTHFS; Belongs to the formate--tetrahydrofolate ligase family (557 aa)
   
  0.970
purD
Phosphoribosylamine--glycine ligase; PFAM- Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; TIGRFAM- Phosphoribosylglycinamide synthetase; HAMAP- Phosphoribosylglycinamide synthetase; KEGG- mca-MCA0361 phosphoribosylamine--glycine ligase; Belongs to the GARS family (426 aa)
   
 
  0.937
purL
Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (1289 aa)
   
   
  0.936
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (127 aa)
   
 
  0.931
Mettu_2825
KEGG- alv-Alvin_2084 chorismate mutase; TIGRFAM- Gamma/beta/epsilon proteobacterial P-protein, chorismate mutase domain; PFAM- Prephenate dehydratase; Chorismate mutase, type II; Amino acid-binding ACT (361 aa)
   
 
  0.925
Your Current Organism:
Methylobacter tundripaludum
NCBI taxonomy Id: 697282
Other names: M. tundripaludum SV96, Methylobacter sp. SV96, Methylobacter tundripaludum, Methylobacter tundripaludum DSM 17260, Methylobacter tundripaludum SV96, Methylobacter tundripaludum str. SV96, Methylobacter tundripaludum strain SV96
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