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fhs protein (Methylobacter tundripaludum) - STRING interaction network
"fhs" - HAMAP: Formate-tetrahydrofolate ligase, FTHFS in Methylobacter tundripaludum
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
fhsHAMAP- Formate-tetrahydrofolate ligase, FTHFS; KEGG- mca-MCA2219 formate--tetrahydrofolate ligase; PFAM- Formate-tetrahydrofolate ligase, FTHFS; Belongs to the formate--tetrahydrofolate ligase family (557 aa)    
Predicted Functional Partners:
Mettu_3646
Methenyltetrahydrofolate cyclohydrolase; KEGG- mpo-Mpop_1750 formiminotransferase-cyclodeaminase; PFAM- Cyclodeaminase/cyclohydrolase (209 aa)
 
 
  0.989
Mettu_0892
FolC bifunctional protein; TIGRFAM- Folylpolyglutamate synthetase; KEGG- mca-MCA2492 folylpolyglutamate synthase/dihydrofolate synthase; PFAM- Mur ligase, central; Mur ligase, C-terminal (423 aa)
   
 
  0.983
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (417 aa)
   
  0.970
Mettu_1405
Methionine synthase; TIGRFAM- 5-methyltetrahydrofolate--homocysteine methyltransferase; KEGG- mca-MCA1545 B12-dependent methionine synthase; PFAM- Homocysteine S-methyltransferase; Dihydropteroate synthase, DHPS; Methionine synthase, cobalamin (vitamin B12)-binding module, cap; Cobalamin (vitamin B12)-binding; Vitamin B12 dependent methionine synthase, activation region (1226 aa)
       
  0.940
purH
Bifunctional purine biosynthesis protein PurH; KEGG- maq-Maqu_3450 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM- AICARFT/IMPCHase bienzyme, formylation region; MGS-like; TIGRFAM- AICARFT/IMPCHase bienzyme; HAMAP- Bifunctional purine biosynthesis protein purH; SMART- AICARFT/IMPCHase bienzyme, formylation region (535 aa)
   
 
  0.889
Mettu_3697
TIGRFAM- Glycine cleavage system T protein; KEGG- pau-PA14_33040 glycine cleavage system protein T2; PFAM- Glycine cleavage T-protein, N-terminal; Glycine cleavage T-protein, C-terminal barrel (360 aa)
   
 
  0.869
Mettu_1997
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (163 aa)
   
 
  0.837
Mettu_1622
TIGRFAM- 5,10-methylenetetrahydrofolate reductase; KEGG- gca-Galf_2647 5,10-methylenetetrahydrofolate reductase; PFAM- Methylenetetrahydrofolate reductase (285 aa)
   
 
  0.772
purD
Phosphoribosylamine--glycine ligase; PFAM- Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; TIGRFAM- Phosphoribosylglycinamide synthetase; HAMAP- Phosphoribosylglycinamide synthetase; KEGG- mca-MCA0361 phosphoribosylamine--glycine ligase; Belongs to the GARS family (426 aa)
   
 
  0.763
purL
Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (1289 aa)
   
   
  0.760
Your Current Organism:
Methylobacter tundripaludum
NCBI taxonomy Id: 697282
Other names: M. tundripaludum SV96, Methylobacter sp. SV96, Methylobacter tundripaludum, Methylobacter tundripaludum DSM 17260, Methylobacter tundripaludum SV96, Methylobacter tundripaludum str. SV96, Methylobacter tundripaludum strain SV96
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