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nth protein (Methylobacter tundripaludum) - STRING interaction network
"nth" - Endonuclease III in Methylobacter tundripaludum
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3’ to the AP site by a beta-elimination, leaving a 3’-terminal unsaturated sugar and a product with a terminal 5’-phosphate (241 aa)    
Predicted Functional Partners:
Mettu_3338
TIGRFAM- Exodeoxyribonuclease III xth; AP endonuclease, family 1; KEGG- exodeoxyribonuclease III xth; PFAM- Endonuclease/exonuclease/phosphatase (254 aa)
 
 
  0.955
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity (930 aa)
   
 
  0.880
Mettu_3402
Electron transport complex subunit E; Part of a membrane complex involved in electron transport (232 aa)
 
   
  0.793
mutL
DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (614 aa)
 
 
  0.662
mfd
Transcription-repair-coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site (1155 aa)
 
 
 
  0.643
fpg
Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3’- and 5’-phosphates (271 aa)
   
   
  0.629
recA
Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (345 aa)
   
 
  0.624
Mettu_3948
KEGG- mca-MCA2051 D,D-heptose 1,7-bisphosphate phosphatase; TIGRFAM- Histidinol-phosphate phosphatase; HAD-superfamily hydrolase, subfamily IIIA; PFAM- Haloacid dehalogenase-like hydrolase (183 aa)
     
 
  0.613
Mettu_1918
TIGRFAM- A/G-specific adenine glycosylase MutY, bacterial form; PFAM- HhH-GPD domain; Endonuclease III-like, iron-sulphur cluster loop motif; KEGG- tgr-Tgr7_2945 A/G-specific DNA-adenine glycosylase; SMART- HhH-GPD domain (349 aa)
   
   
  0.577
Mettu_1913
KEGG- spl-Spea_1502 hypothetical protein (132 aa)
              0.559
Your Current Organism:
Methylobacter tundripaludum
NCBI taxonomy Id: 697282
Other names: M. tundripaludum SV96, Methylobacter sp. SV96, Methylobacter tundripaludum, Methylobacter tundripaludum DSM 17260, Methylobacter tundripaludum SV96, Methylobacter tundripaludum str. SV96, Methylobacter tundripaludum strain SV96
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