| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Mettu_0892 | Mettu_1832 | Mettu_0892 | Mettu_1832 | FolC bifunctional protein | Deoxyuridine 5’-triphosphate nucleotidohydrolase ; This enzyme is involved in nucleotide metabolism- it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA | 0.403 |
| Mettu_0892 | Mettu_1997 | Mettu_0892 | Mettu_1997 | FolC bifunctional protein | Dihydrofolate reductase ; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | 0.995 |
| Mettu_0892 | glyA | Mettu_0892 | Mettu_1433 | FolC bifunctional protein | Serine hydroxymethyltransferase ; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | 0.973 |
| Mettu_0892 | thyA | Mettu_0892 | Mettu_1994 | FolC bifunctional protein | Thymidylate synthase ; Provides the sole de novo source of dTMP for DNA biosynthesis | 0.901 |
| Mettu_1405 | Mettu_1997 | Mettu_1405 | Mettu_1997 | Methionine synthase | Dihydrofolate reductase ; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | 0.893 |
| Mettu_1405 | gcvP | Mettu_1405 | Mettu_3696 | Methionine synthase | Glycine dehydrogenase (aminomethyl-transferring) ; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein | 0.937 |
| Mettu_1405 | glyA | Mettu_1405 | Mettu_1433 | Methionine synthase | Serine hydroxymethyltransferase ; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | 0.943 |
| Mettu_1405 | thyA | Mettu_1405 | Mettu_1994 | Methionine synthase | Thymidylate synthase ; Provides the sole de novo source of dTMP for DNA biosynthesis | 0.904 |
| Mettu_1832 | Mettu_0892 | Mettu_1832 | Mettu_0892 | Deoxyuridine 5’-triphosphate nucleotidohydrolase ; This enzyme is involved in nucleotide metabolism- it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA | FolC bifunctional protein | 0.403 |
| Mettu_1832 | Mettu_1953 | Mettu_1832 | Mettu_1953 | Deoxyuridine 5’-triphosphate nucleotidohydrolase ; This enzyme is involved in nucleotide metabolism- it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA | DNA polymerase III subunit beta ; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3’ to 5’ exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA | 0.990 |
| Mettu_1832 | Mettu_1997 | Mettu_1832 | Mettu_1997 | Deoxyuridine 5’-triphosphate nucleotidohydrolase ; This enzyme is involved in nucleotide metabolism- it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA | Dihydrofolate reductase ; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | 0.654 |
| Mettu_1832 | Mettu_3679 | Mettu_1832 | Mettu_3679 | Deoxyuridine 5’-triphosphate nucleotidohydrolase ; This enzyme is involved in nucleotide metabolism- it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent | 0.993 |
| Mettu_1832 | Mettu_3680 | Mettu_1832 | Mettu_3680 | Deoxyuridine 5’-triphosphate nucleotidohydrolase ; This enzyme is involved in nucleotide metabolism- it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA | Ribonucleotide reductase, alpha subunit | 0.992 |
| Mettu_1832 | thyA | Mettu_1832 | Mettu_1994 | Deoxyuridine 5’-triphosphate nucleotidohydrolase ; This enzyme is involved in nucleotide metabolism- it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA | Thymidylate synthase ; Provides the sole de novo source of dTMP for DNA biosynthesis | 0.999 |
| Mettu_1832 | tmk | Mettu_1832 | Mettu_0828 | Deoxyuridine 5’-triphosphate nucleotidohydrolase ; This enzyme is involved in nucleotide metabolism- it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA | dTMP kinase ; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis | 0.961 |
| Mettu_1953 | Mettu_1832 | Mettu_1953 | Mettu_1832 | DNA polymerase III subunit beta ; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3’ to 5’ exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA | Deoxyuridine 5’-triphosphate nucleotidohydrolase ; This enzyme is involved in nucleotide metabolism- it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA | 0.990 |
| Mettu_1953 | Mettu_1997 | Mettu_1953 | Mettu_1997 | DNA polymerase III subunit beta ; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3’ to 5’ exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA | Dihydrofolate reductase ; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | 0.607 |
| Mettu_1953 | Mettu_3679 | Mettu_1953 | Mettu_3679 | DNA polymerase III subunit beta ; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3’ to 5’ exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent | 0.992 |
| Mettu_1953 | Mettu_3680 | Mettu_1953 | Mettu_3680 | DNA polymerase III subunit beta ; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3’ to 5’ exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA | Ribonucleotide reductase, alpha subunit | 0.991 |
| Mettu_1953 | thyA | Mettu_1953 | Mettu_1994 | DNA polymerase III subunit beta ; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3’ to 5’ exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA | Thymidylate synthase ; Provides the sole de novo source of dTMP for DNA biosynthesis | 0.963 |
