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thyA protein (Methylobacter tundripaludum) - STRING interaction network
"thyA" - Thymidylate synthase in Methylobacter tundripaludum
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second shell of interactors
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some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
thyAThymidylate synthase ; Provides the sole de novo source of dTMP for DNA biosynthesis (277 aa)    
Predicted Functional Partners:
Mettu_1997
Dihydrofolate reductase ; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (163 aa)
 
  0.999
Mettu_1832
Deoxyuridine 5’-triphosphate nucleotidohydrolase ; This enzyme is involved in nucleotide metabolism- it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (154 aa)
   
  0.999
tmk
dTMP kinase ; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (223 aa)
   
 
  0.998
Mettu_1953
DNA polymerase III subunit beta ; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3’ to 5’ exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (366 aa)
     
 
  0.963
glyA
Serine hydroxymethyltransferase ; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (417 aa)
   
 
  0.942
Mettu_3679
Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent (716 aa)
   
   
  0.941
gcvP
Glycine dehydrogenase (aminomethyl-transferring) ; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (963 aa)
   
  0.935
Mettu_3680
Ribonucleotide reductase, alpha subunit (254 aa)
   
   
  0.918
Mettu_1405
Methionine synthase (1226 aa)
       
  0.904
Mettu_0892
FolC bifunctional protein (423 aa)
     
 
  0.901
Your Current Organism:
Methylobacter tundripaludum
NCBI taxonomy Id: 697282
Other names: M. tundripaludum, M. tundripaludum SV96, Methylobacter, Methylobacter sp. SV96, Methylobacter tundripaludum, Methylobacter tundripaludum DSM 17260, Methylobacter tundripaludum SV96, Methylobacter tundripaludum Wartiainen et al. 2006, Methylobacter tundripaludum str. SV96, Methylobacter tundripaludum strain SV96
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