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Mettu_1997 protein (Methylobacter tundripaludum) - STRING interaction network
"Mettu_1997" - Dihydrofolate reductase in Methylobacter tundripaludum
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
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gene co-occurrence
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textmining
co-expression
protein homology
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Mettu_1997Dihydrofolate reductase ; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (163 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase ; Provides the sole de novo source of dTMP for DNA biosynthesis (277 aa)
 
  0.999
Mettu_0892
FolC bifunctional protein (423 aa)
   
 
  0.995
glyA
Serine hydroxymethyltransferase ; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (417 aa)
   
 
  0.924
gcvP
Glycine dehydrogenase (aminomethyl-transferring) ; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (963 aa)
       
  0.910
fmt
Methionyl-tRNA formyltransferase ; Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by- (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (309 aa)
 
 
  0.908
fhs
Formyltetrahydrofolate synthetase (557 aa)
   
 
  0.899
Mettu_1405
Methionine synthase (1226 aa)
   
 
  0.893
Mettu_3697
Aminomethyltransferase ; The glycine cleavage system catalyzes the degradation of glycine (360 aa)
   
 
  0.892
Mettu_2918
Dihydropteroate pyrophosphorylase ; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives (303 aa)
   
   
  0.888
Mettu_2457
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (167 aa)
 
   
  0.885
Your Current Organism:
Methylobacter tundripaludum
NCBI taxonomy Id: 697282
Other names: M. tundripaludum, M. tundripaludum SV96, Methylobacter, Methylobacter sp. SV96, Methylobacter tundripaludum, Methylobacter tundripaludum DSM 17260, Methylobacter tundripaludum SV96, Methylobacter tundripaludum Wartiainen et al. 2006, Methylobacter tundripaludum str. SV96, Methylobacter tundripaludum strain SV96
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