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STRINGSTRING
Mettu_2231 protein (Methylobacter tundripaludum) - STRING interaction network
"Mettu_2231" - PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase in Methylobacter tundripaludum
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
Mettu_2231PFAM- Dihydroxy-acid/6-phosphogluconate dehydratase; TIGRFAM- Dihydroxy-acid dehydratase; HAMAP- Dihydroxy-acid dehydratase; KEGG- mmb-Mmol_0396 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family (617 aa)    
Predicted Functional Partners:
ilvC
Ketol-acid reductoisomerase (NADP(+)); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate; Belongs to the ketol-acid reductoisomerase family (338 aa)
 
  0.999
ilvE
Branched-chain-amino-acid aminotransferase; Acts on leucine, isoleucine and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family (308 aa)
   
  0.994
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily (514 aa)
 
 
  0.987
Mettu_3267
(R)-citramalate synthase; KEGG- alv-Alvin_2959 pyruvate carboxyltransferase; PFAM- Pyruvate carboxyltransferase; 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; Belongs to the alpha-IPM synthase/homocitrate synthase family (514 aa)
 
 
  0.979
Mettu_2397
TIGRFAM- Acetolactate synthase, large subunit, biosynthetic; KEGG- mca-MCA2270 acetolactate synthase, large subunit, biosynthetic type; PFAM- Thiamine pyrophosphate enzyme, N-terminal TPP binding region; Thiamine pyrophosphate enzyme, central region; Thiamine pyrophosphate enzyme, C-terminal TPP-binding (578 aa)
  0.961
leuC
3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate; Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily (472 aa)
 
 
  0.892
Mettu_0826
TIGRFAM- Aminodeoxychorismate lyase, class IV; KEGG- noc-Noc_1662 aminotransferase, class IV; PFAM- Aminotransferase, class IV; overlaps another CDS with the same product name (283 aa)
   
  0.892
Mettu_1398
D-amino-acid transaminase; KEGG- mca-MCA0106 D-amino acid aminotransferase, putative; PFAM- Aminotransferase, class IV (280 aa)
   
  0.892
Mettu_2398
KEGG- mca-MCA2271 acetolactate synthase, small subunit; TIGRFAM- Acetolactate synthase, small subunit; PFAM- Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT (163 aa)
 
  0.878
Mettu_3921
PFAM- 3-hydroxyacyl-CoA dehydrogenase, NAD binding; 3-hydroxyacyl-CoA dehydrogenase, C-terminal; Crotonase, core; KEGG- rce-RC1_1947 3-hydroxyacyl-CoA dehydrogenase, putative (779 aa)
   
 
  0.826
Your Current Organism:
Methylobacter tundripaludum
NCBI taxonomy Id: 697282
Other names: M. tundripaludum SV96, Methylobacter sp. SV96, Methylobacter tundripaludum, Methylobacter tundripaludum DSM 17260, Methylobacter tundripaludum SV96, Methylobacter tundripaludum str. SV96, Methylobacter tundripaludum strain SV96
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