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hemC protein (Methylobacter tundripaludum) - STRING interaction network
"hemC" - Porphobilinogen deaminase in Methylobacter tundripaludum
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps; Belongs to the HMBS family (313 aa)    
Predicted Functional Partners:
Mettu_2437
PFAM- Tetrapyrrole biosynthesis, uroporphyrinogen III synthase; KEGG- nhl-Nhal_3935 uroporphyrinogen III synthase HEM4 (256 aa)
  0.999
Mettu_2540
KEGG- mca-MCA2793 delta-aminolevulinic acid dehydratase; PFAM- Tetrapyrrole biosynthesis, porphobilinogen synthase; Belongs to the ALAD family (334 aa)
 
  0.999
cysG
Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme (464 aa)
 
  0.997
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (355 aa)
  0.992
hemA
Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA); Belongs to the glutamyl-tRNA reductase family (419 aa)
   
  0.979
Mettu_2781
Magnesium chelatase; PFAM- von Willebrand factor, type A; Magnesium chelatase, ChlI subunit; KEGG- hse-Hsero_2656 Mg-chelatase subunit ChlI protein; SMART- von Willebrand factor, type A; ATPase, AAA+ type, core (629 aa)
   
   
  0.953
hemL
Glutamate-1-semialdehyde 2,1-aminomutase; PFAM- Aminotransferase class-III; TIGRFAM- Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase; HAMAP- Glutamate-1-semialdehyde 2,1-aminomutase; KEGG- alv-Alvin_0103 glutamate-1-semialdehyde-2,1-aminomutase (426 aa)
 
 
  0.950
Mettu_2438
HemX domain protein; PFAM- HemX; KEGG- mca-MCA3061 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase (439 aa)
   
 
  0.922
Mettu_2439
HemY domain protein; PFAM- HemY, N-terminal; KEGG- mca-MCA3062 HemY protein, putative (410 aa)
   
   
  0.887
Mettu_0723
KEGG- gca-Galf_1632 uroporphyrinogen decarboxylase (URO-D) (342 aa)
   
  0.795
Your Current Organism:
Methylobacter tundripaludum
NCBI taxonomy Id: 697282
Other names: M. tundripaludum SV96, Methylobacter sp. SV96, Methylobacter tundripaludum, Methylobacter tundripaludum DSM 17260, Methylobacter tundripaludum SV96, Methylobacter tundripaludum str. SV96, Methylobacter tundripaludum strain SV96
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