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gcvH protein (Methylobacter tundripaludum) - STRING interaction network
"gcvH" - Glycine cleavage system H protein in Methylobacter tundripaludum
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (127 aa)    
Predicted Functional Partners:
Mettu_3697
TIGRFAM- Glycine cleavage system T protein; KEGG- pau-PA14_33040 glycine cleavage system protein T2; PFAM- Glycine cleavage T-protein, N-terminal; Glycine cleavage T-protein, C-terminal barrel (360 aa)
  0.999
gcvP
Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family (963 aa)
  0.999
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (417 aa)
   
 
  0.931
Mettu_1405
Methionine synthase; TIGRFAM- 5-methyltetrahydrofolate--homocysteine methyltransferase; KEGG- mca-MCA1545 B12-dependent methionine synthase; PFAM- Homocysteine S-methyltransferase; Dihydropteroate synthase, DHPS; Methionine synthase, cobalamin (vitamin B12)-binding module, cap; Cobalamin (vitamin B12)-binding; Vitamin B12 dependent methionine synthase, activation region (1226 aa)
       
  0.917
Mettu_1622
TIGRFAM- 5,10-methylenetetrahydrofolate reductase; KEGG- gca-Galf_2647 5,10-methylenetetrahydrofolate reductase; PFAM- Methylenetetrahydrofolate reductase (285 aa)
   
 
  0.880
Mettu_0758
KEGG- mca-MCA2039 glutamate synthase, large subunit; PFAM- Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, central-C; Glutamate synthase, alpha subunit, C-terminal (1539 aa)
     
 
  0.813
lipA
Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (320 aa)
 
 
  0.810
Mettu_1417
KEGG- mca-MCA1406 serine--glyoxylate aminotransferase; PFAM- Aminotransferase, class V/Cysteine desulfurase (388 aa)
     
 
  0.808
Mettu_3793
PFAM- Oxidoreductase FAD/NAD(P)-binding; KEGG- mca-MCA0335 hypothetical protein (1230 aa)
     
 
  0.795
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2’-deoxyuridine- 5’-monophosphate (dUMP) to 2’-deoxythymidine-5’-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis (277 aa)
   
 
  0.793
Your Current Organism:
Methylobacter tundripaludum
NCBI taxonomy Id: 697282
Other names: M. tundripaludum SV96, Methylobacter sp. SV96, Methylobacter tundripaludum, Methylobacter tundripaludum DSM 17260, Methylobacter tundripaludum SV96, Methylobacter tundripaludum str. SV96, Methylobacter tundripaludum strain SV96
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