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ispF protein (Methylobacter tundripaludum) - STRING interaction network
"ispF" - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase in Methylobacter tundripaludum
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ispF2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (157 aa)    
Predicted Functional Partners:
ispD
MEP cytidylyltransferase ; Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (230 aa)
 
  0.999
dxr
2-C-methyl-D-erythritol 4-phosphate synthase ; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (394 aa)
 
  0.996
ispE
4-(cytidine-5’-diphospho)-2-C-methyl-D-erythritol kinase ; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (292 aa)
 
 
  0.995
ispG
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase ; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (405 aa)
 
 
  0.992
ispH
4-hydroxy-3-methylbut-2-enyl diphosphate reductase ; Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (315 aa)
 
   
  0.933
dxs
1-deoxyxylulose-5-phosphate synthase ; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (620 aa)
 
   
  0.921
trmD
tRNA [GM37] methyltransferase ; Specifically methylates guanosine-37 in various tRNAs (245 aa)
   
    0.913
metK
Methionine adenosyltransferase ; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme (386 aa)
            0.808
hisE
Phosphoribosyl-ATP pyrophosphatase (105 aa)
 
            0.776
ftsB
Cell division protein FtsB ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (89 aa)
   
        0.761
Your Current Organism:
Methylobacter tundripaludum
NCBI taxonomy Id: 697282
Other names: M. tundripaludum, M. tundripaludum SV96, Methylobacter, Methylobacter sp. SV96, Methylobacter tundripaludum, Methylobacter tundripaludum DSM 17260, Methylobacter tundripaludum SV96, Methylobacter tundripaludum Wartiainen et al. 2006, Methylobacter tundripaludum str. SV96, Methylobacter tundripaludum strain SV96
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