node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mettu_0644 | Mettu_3579 | Mettu_0644 | Mettu_3579 | TIGRFAM- Adenylosuccinate lyase; KEGG- tgr-Tgr7_1849 adenylosuccinate lyase; PFAM- Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily | PFAM- Phosphoribosyltransferase; KEGG- nhl-Nhal_2865 phosphoribosyltransferase | 0.806 |
Mettu_0644 | guaA | Mettu_0644 | Mettu_1868 | TIGRFAM- Adenylosuccinate lyase; KEGG- tgr-Tgr7_1849 adenylosuccinate lyase; PFAM- Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP | 0.960 |
Mettu_0644 | guaB | Mettu_0644 | Mettu_1869 | TIGRFAM- Adenylosuccinate lyase; KEGG- tgr-Tgr7_1849 adenylosuccinate lyase; PFAM- Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily | Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family | 0.849 |
Mettu_0644 | purA | Mettu_0644 | Mettu_2976 | TIGRFAM- Adenylosuccinate lyase; KEGG- tgr-Tgr7_1849 adenylosuccinate lyase; PFAM- Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family | 0.998 |
Mettu_0644 | purH | Mettu_0644 | Mettu_2626 | TIGRFAM- Adenylosuccinate lyase; KEGG- tgr-Tgr7_1849 adenylosuccinate lyase; PFAM- Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily | Bifunctional purine biosynthesis protein PurH; KEGG- maq-Maqu_3450 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM- AICARFT/IMPCHase bienzyme, formylation region; MGS-like; TIGRFAM- AICARFT/IMPCHase bienzyme; HAMAP- Bifunctional purine biosynthesis protein purH; SMART- AICARFT/IMPCHase bienzyme, formylation region | 0.998 |
Mettu_0644 | purL | Mettu_0644 | Mettu_3166 | TIGRFAM- Adenylosuccinate lyase; KEGG- tgr-Tgr7_1849 adenylosuccinate lyase; PFAM- Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate | 0.992 |
Mettu_0644 | pyrB | Mettu_0644 | Mettu_1596 | TIGRFAM- Adenylosuccinate lyase; KEGG- tgr-Tgr7_1849 adenylosuccinate lyase; PFAM- Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily | PFAM- Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; TIGRFAM- Aspartate carbamoyltransferase, eukaryotic; HAMAP- Aspartate carbamoyltransferase; KEGG- mca-MCA2333 aspartate carbamoyltransferase catalytic subunit; Belongs to the ATCase/OTCase family | 0.469 |
Mettu_2038 | Mettu_3579 | Mettu_2038 | Mettu_3579 | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family | PFAM- Phosphoribosyltransferase; KEGG- nhl-Nhal_2865 phosphoribosyltransferase | 0.788 |
Mettu_2038 | guaA | Mettu_2038 | Mettu_1868 | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP | 0.947 |
Mettu_2038 | guaB | Mettu_2038 | Mettu_1869 | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family | Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family | 0.974 |
Mettu_2038 | purA | Mettu_2038 | Mettu_2976 | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family | 0.856 |
Mettu_3579 | Mettu_0644 | Mettu_3579 | Mettu_0644 | PFAM- Phosphoribosyltransferase; KEGG- nhl-Nhal_2865 phosphoribosyltransferase | TIGRFAM- Adenylosuccinate lyase; KEGG- tgr-Tgr7_1849 adenylosuccinate lyase; PFAM- Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily | 0.806 |
Mettu_3579 | Mettu_2038 | Mettu_3579 | Mettu_2038 | PFAM- Phosphoribosyltransferase; KEGG- nhl-Nhal_2865 phosphoribosyltransferase | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family | 0.788 |
Mettu_3579 | guaA | Mettu_3579 | Mettu_1868 | PFAM- Phosphoribosyltransferase; KEGG- nhl-Nhal_2865 phosphoribosyltransferase | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP | 0.953 |
Mettu_3579 | guaB | Mettu_3579 | Mettu_1869 | PFAM- Phosphoribosyltransferase; KEGG- nhl-Nhal_2865 phosphoribosyltransferase | Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family | 0.896 |
Mettu_3579 | purA | Mettu_3579 | Mettu_2976 | PFAM- Phosphoribosyltransferase; KEGG- nhl-Nhal_2865 phosphoribosyltransferase | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family | 0.917 |
Mettu_3579 | purH | Mettu_3579 | Mettu_2626 | PFAM- Phosphoribosyltransferase; KEGG- nhl-Nhal_2865 phosphoribosyltransferase | Bifunctional purine biosynthesis protein PurH; KEGG- maq-Maqu_3450 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM- AICARFT/IMPCHase bienzyme, formylation region; MGS-like; TIGRFAM- AICARFT/IMPCHase bienzyme; HAMAP- Bifunctional purine biosynthesis protein purH; SMART- AICARFT/IMPCHase bienzyme, formylation region | 0.854 |
Mettu_3579 | purL | Mettu_3579 | Mettu_3166 | PFAM- Phosphoribosyltransferase; KEGG- nhl-Nhal_2865 phosphoribosyltransferase | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate | 0.479 |
argG | guaA | Mettu_1221 | Mettu_1868 | PFAM- Argininosuccinate synthase; TIGRFAM- Argininosuccinate synthase; HAMAP- Argininosuccinate synthase; KEGG- mca-MCA1099 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP | 0.555 |
argG | purA | Mettu_1221 | Mettu_2976 | PFAM- Argininosuccinate synthase; TIGRFAM- Argininosuccinate synthase; HAMAP- Argininosuccinate synthase; KEGG- mca-MCA1099 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family | 0.903 |