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hisZ protein (Methylobacter tundripaludum) - STRING interaction network
"hisZ" - ATP phosphoribosyltransferase regulatory subunit in Methylobacter tundripaludum
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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hisZATP phosphoribosyltransferase regulatory subunit ; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (411 aa)    
Predicted Functional Partners:
hisG
ATP phosphoribosyltransferase ; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N’-(5’-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (209 aa)
 
  0.999
hisE
Phosphoribosyl-ATP pyrophosphatase (105 aa)
 
   
  0.996
hisI
Phosphoribosyl-AMP cyclohydrolase ; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP (130 aa)
       
  0.937
purA
IMP--aspartate ligase ; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (430 aa)
   
        0.885
prs
Phosphoribosyl pyrophosphate synthase ; Involved in the biosynthesis of ribose 1,5-bisphosphate. Catalyzes the transfer of pyrophosphoryl group from ATP to ribose- 5-phosphate to yield phosphoribosyl diphosphate (PRPP) and AMP (317 aa)
     
 
    0.880
Mettu_2979
HflK protein (399 aa)
              0.824
Mettu_2978
Protein HflC ; HflC and HflK could regulate a protease (284 aa)
              0.824
Mettu_1489
Ribose-phosphate pyrophosphokinase (292 aa)
     
 
    0.786
Mettu_2975
Putative uncharacterized protein (95 aa)
              0.748
hisF
ImGP synthase subunit HisF ; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (257 aa)
       
  0.745
Your Current Organism:
Methylobacter tundripaludum
NCBI taxonomy Id: 697282
Other names: M. tundripaludum, M. tundripaludum SV96, Methylobacter, Methylobacter sp. SV96, Methylobacter tundripaludum, Methylobacter tundripaludum DSM 17260, Methylobacter tundripaludum SV96, Methylobacter tundripaludum Wartiainen et al. 2006, Methylobacter tundripaludum str. SV96, Methylobacter tundripaludum strain SV96
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