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birA protein (Methylobacter tundripaludum) - STRING interaction network
"birA" - Biotin-[acetyl-CoA carboxylase] synthetase in Methylobacter tundripaludum
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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birABiotin-[acetyl-CoA carboxylase] synthetase ; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5’-adenylate (BirA-bio- 5’-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon (332 aa)    
Predicted Functional Partners:
Mettu_2618
Oxaloacetate decarboxylase alpha subunit (601 aa)
 
  0.998
Mettu_2635
Acetyl-CoA carboxylase, biotin carboxyl carrier protein (145 aa)
 
  0.989
coaX
Pantothenic acid kinase ; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (243 aa)
 
   
  0.972
Mettu_2634
Acetyl-CoA carboxylase, biotin carboxylase (447 aa)
  0.970
bioB
Biotin synthase ; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (322 aa)
   
 
  0.959
Mettu_0026
Cysteine desulfurase (368 aa)
 
   
  0.942
Mettu_3390
Cysteine desulfurase NifS (402 aa)
       
  0.934
Mettu_1821
NAD+ synthetase (536 aa)
   
 
  0.929
ribB
3,4-dihydroxy-2-butanone 4-phosphate synthase ; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (367 aa)
         
  0.864
purL
Formylglycinamide ribonucleotide amidotransferase ; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (1289 aa)
         
  0.863
Your Current Organism:
Methylobacter tundripaludum
NCBI taxonomy Id: 697282
Other names: M. tundripaludum, M. tundripaludum SV96, Methylobacter, Methylobacter sp. SV96, Methylobacter tundripaludum, Methylobacter tundripaludum DSM 17260, Methylobacter tundripaludum SV96, Methylobacter tundripaludum Wartiainen et al. 2006, Methylobacter tundripaludum str. SV96, Methylobacter tundripaludum strain SV96
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