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birA protein (Methylobacter tundripaludum) - STRING interaction network
"birA" - Bifunctional ligase/repressor BirA in Methylobacter tundripaludum
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second shell of interactors
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filled nodes:
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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birABifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5’-adenylate (BirA-bio- 5’-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon (332 aa)    
Predicted Functional Partners:
coaX
Type III pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (243 aa)
 
        0.960
bioD
ATP-dependent dethiobiotin synthetase BioD; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (219 aa)
 
 
  0.956
bioB
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family (322 aa)
   
 
  0.947
Mettu_2618
TIGRFAM- Oxaloacetate decarboxylase, alpha subunit; KEGG- pmy-Pmen_2893 oxaloacetate decarboxylase; PFAM- Conserved carboxylase region; Pyruvate carboxyltransferase; Biotin/lipoyl attachment (601 aa)
 
 
  0.945
Mettu_2635
Biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA (145 aa)
 
 
 
  0.911
panC
Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate; Belongs to the pantothenate synthetase family (280 aa)
   
 
  0.907
Mettu_2634
TIGRFAM- Acetyl-CoA carboxylase, biotin carboxylase; KEGG- tgr-Tgr7_0368 acetyl-CoA carboxylase, biotin carboxylase; PFAM- Carbamoyl phosphate synthetase, large subunit, ATP-binding; Carbamoyl phosphate synthase, large subunit, N-terminal; Biotin carboxylase, C-terminal (447 aa)
  0.876
Mettu_0822
TIGRFAM- Malonyl CoA-acyl carrier protein transacylase; KEGG- mca-MCA2002 malonyl CoA-acyl carrier protein transacylase; PFAM- Acyl transferase (318 aa)
 
 
  0.873
Mettu_4075
PFAM- Type IV pilus assembly PilZ; KEGG- dak-DaAHT2_1202 type IV pilus assembly PilZ (202 aa)
              0.863
guaB
Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family (488 aa)
         
  0.857
Your Current Organism:
Methylobacter tundripaludum
NCBI taxonomy Id: 697282
Other names: M. tundripaludum SV96, Methylobacter sp. SV96, Methylobacter tundripaludum, Methylobacter tundripaludum DSM 17260, Methylobacter tundripaludum SV96, Methylobacter tundripaludum str. SV96, Methylobacter tundripaludum strain SV96
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