STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nadDNicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (211 aa)    
Predicted Functional Partners:
AEM78437.1
Metal dependent phosphohydrolase; TIGRFAM: Conserved hypothetical protein CHP00488; HDIG; PFAM: Metal-dependent phosphohydrolase, HD region, subdomain; KEGG: tit:Thit_0857 metal dependent phosphohydrolase; SMART: Metal-dependent phosphohydrolase, HD region.
 
  
 0.996
cinA
KEGG: tbo:Thebr_1221 competence/damage-inducible protein CinA; TIGRFAM: Competence-induced protein CinA; CinA, C-terminal; PFAM: CinA, C-terminal; Molybdopterin binding; Belongs to the CinA family.
  
 
 0.977
nadE
NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
 
 0.969
AEM78393.1
PFAM: Quinolinate phosphoribosyl transferase; KEGG: tbo:Thebr_1506 quinolinate phosphoribosyl transferase; Belongs to the NAPRTase family.
 
 
 0.967
rsfS
Iojap-like protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
 
  
 0.948
nadK
Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
 
 
 0.948
cobB
NAD-dependent deacetylase; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily.
   
 0.929
surE
Multifunctional protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
     
 0.902
AEM77883.1
KEGG: tbo:Thebr_1985 5'-nucleotidase domain-containing protein; PFAM: 5'-Nucleotidase, C-terminal; Metallophosphoesterase; SH3, type 3; SMART: Bacterial SH3-like region.
     
  0.900
AEM78438.1
KEGG: tmt:Tmath_0900 cell envelope-related transcriptional attenuator; TIGRFAM: Cell envelope-related transcriptional attenuator; PFAM: Cell envelope-related transcriptional attenuator.
     
 0.821
Your Current Organism:
Thermoanaerobacter wiegelii
NCBI taxonomy Id: 697303
Other names: T. wiegelii Rt8.B1, Thermoanaerobacter wiegelii Rt8.B1, Thermoanaerobacter wiegelii str. Rt8.B1, Thermoanaerobacter wiegelii strain Rt8.B1
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