STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PH0052227aa long hypothetical fibrillarin-like pre-rRNA processing protein; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family. (227 aa)    
Predicted Functional Partners:
PH0053
404aa long hypothetical protein; Similar to PIR:F64386 percent identity: 52.669 in 283aa; owl:CEK07C53 percent identity: 39.249 in 306aa; owl:HSNOP56 percent identity: 41.102 in 239aa.
 
 
 0.999
PH0615
125aa long hypothetical 30S ribosomal protein S6E; Similar to Swiss_Prot:P54067 percent identity: 64.545 in 124aa. motif=ribosomal protein S6e signature; Belongs to the eukaryotic ribosomal protein eS6 family.
   
 0.999
PH1379
229aa long hypothetical protein; Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
  
 0.999
PH1496
124aa long hypothetical 50S ribosomal protein L7; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, box H/ACA, box C/D and box C'/D' sRNAs (By similarity). When added to reconstituted ribonuclease P (RNase P) it increases the optimum temperature to that of the partially purified enzyme and causes a 5-fold increase in apparent Vmax. Binds the RNase P catalytic RNA.
   
 
 0.999
PH1566
219aa long hypothetical protein; Similar to PIR:C64355 percent identity: 50.575 in 177aa.
   
 0.999
PH1757
236aa long hypothetical 30S ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy.
  
 0.999
PH1640
180aa long hypothetical 30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
 
 0.996
PH1633
135aa long hypothetical 30S ribosomal protein S9; Similar to Swiss_Prot:P54024 percent identity: 64.925 in 134aa; Swiss_Prot:P05763 percent identity: 51.908 in 133aa; owl:SS56KBFR53 percent identity: 49.242 in 134aa. motif=ribosomal protein S9 signature; Belongs to the universal ribosomal protein uS9 family.
 
 0.984
PH1638
137aa long hypothetical 30S ribosomal protein S11; Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family.
  
 0.976
PH1899
735aa long hypothetical elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation facto [...]
  
 0.955
Your Current Organism:
Pyrococcus horikoshii
NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.