STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PH0597376aa long hypothetical dehydrogenase; Similar to owl:BSZ9404317 percent identity: 49.821 in 287aa; Swiss_Prot:P37666 percent identity: 43.750 in 327aa; PIR:A64427 percent identity: 42.633 in 330aa. motif=ATP/GTP-binding site motif A (P-loop); D-isomer specific 2-hydroxyacid dehydrogenases s. (376 aa)    
Predicted Functional Partners:
PH0495
440aa long hypothetical protein; Catalyzes the ATP-dependent phosphorylation of D-glycerate to 2-phosphoglycerate. It can also utilize GTP, CTP, UTP, ADP or pyrophosphate as phosphate donor.
 
 
 0.947
PH1421
231aa long hypothetical protein; Catalyzes the dephosphorylation of 2-phosphoglycolate (By similarity). Has phosphatase activity towards p-nitrophenylphosphate (in vitro); Belongs to the archaeal SPP-like hydrolase family.
  
 
 0.923
PH1722
323aa long hypothetical 3-isopropylmalate dehydrogenase; May play a dual role in glutamate and lysine biosynthesis in vivo. Uses isocitrate and homoisocitrate at near equal efficiency and preferentially uses NAD over NADP.
 
  
 0.736
PH0598
339aa long hypothetical protein.
       0.572
PH1901
282aa long hypothetical dehydrogenase; Similar to owl:CELF36H9 percent identity:34.711 in 254aa.
 
 
 0.462
PH0570
478aa long hypothetical pyruvate kinase; Similar to PIR:A57418 percent identity:76.037 in 217aa; PIR:S76677 percent identity:42.128 in 484aa; Swiss_Prot:Q02499 percent identity:43.991 in 475aa. motif=eukaryotic thiol (cysteine) proteases active sites; Belongs to the pyruvate kinase family.
  
 
 0.457
PH1776
255aa long hypothetical 50S ribosomal protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
  
 
 0.457
PH1809
261aa long hypothetical glucose 1-dehydrogenase; Similar to Swiss_Prot:P39640 percent identity:29.098 in 252aa; Swiss_Prot:P39484 percent identity:29.461 in 255aa.
 
 
 0.422
PH1202
371aa long hypothetical protein; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
  
  
 0.418
PH1308
386aa long hypothetical serine aminotransferase; Similar to PIR:G64419 percent identity: 34.637 in 362aa; PIR:JC2256 percent identity: 33.803 in 360aa; owl:S75916 percent identity: 34.551 in 364aa.
  
  
 0.416
Your Current Organism:
Pyrococcus horikoshii
NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.