STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PH0725265aa long hypothetical diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. (265 aa)    
Predicted Functional Partners:
PH1899
735aa long hypothetical elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation facto [...]
    
 0.999
PH1105
342aa long hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).
  
 0.972
PH1257
227aa long hypothetical protein; Similar to owl:B64371 percent identity: 58.986 in 218aa.
 
  
 0.908
PH0375
221aa long hypothetical protein; Similar to PIR:B64371 percent identity:29.000 in 210aa.
 
  
 0.830
PH0724
274aa long hypothetical protein.
     
 0.787
PH0854
137aa long hypothetical protein; Similar to Swiss_Prot:P37552 percent identity: 55.738 in 123aa; owl:HPAE0006038 percent identity: 53.600 in 125aa; Swiss_Prot:P39330 percent identity: 56.098 in 127aa; Belongs to the RutC family.
     
 0.771
PH0114
316aa long hypothetical molybdenum cofactor biosynthesis protein; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family.
      
 0.647
PH1416
330aa long hypothetical protein; Similar to PIR:C64410 percent identity: 45.625 in 343aa; PIR:D64494 percent identity: 40.097 in 212aa.
 
  
 0.635
PH1867
617aa long hypothetical protein; Similar to PIR:G64441 percent identity: 54.442 in 577aa; owl:CEZK8632 percent identity: 45.265 in 581aa; owl:SPAC29A418 percent identity: 45.977 in 576aa.
  
  
 0.618
PH0615
125aa long hypothetical 30S ribosomal protein S6E; Similar to Swiss_Prot:P54067 percent identity: 64.545 in 124aa. motif=ribosomal protein S6e signature; Belongs to the eukaryotic ribosomal protein eS6 family.
  
     0.573
Your Current Organism:
Pyrococcus horikoshii
NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.