STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PH0852450aa long hypothetical adenylosuccinate lyase; Similar to PIR:A64416 percent identity: 58.864 in 443aa; Swiss_Prot:P12047 percent identity: 42.373 in 419aa; owl:S76222 percent identity: 41.769 in 414aa. motif=fumarate lyases signature. (450 aa)    
Predicted Functional Partners:
PH0239
238aa long hypothetical phosphoribosylaminoimidazole-succinocarboxamide synthase; Similar to PIR:G64498 percent identity: 52.814 in 232aa; Swiss_Prot:P12046 percent identity: 49.785 in 235aa; Swiss_Prot:Q07296 percent identity: 48.214 in 227aa. motif=SAICAR synthetase signatures.
 
 0.999
PH0438
339aa long hypothetical adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
 0.999
PH0240
449aa long hypothetical amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
  
 
 0.993
PH0323
438aa long hypothetical phosphoribosylamide--glycine ligase; Similar to PIR:A64417 percent identity: 55.478 in 442aa; owl:HUMRPS4 percent identity: 33.738 in 424aa; Swiss_Prot:P12039 percent identity: 33.819 in 352aa. motif=prokaryotic membrane lipoprotein lipid attachment site.
  
 
 0.993
PH1953
705aa long hypothetical phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL a [...]
 
  
 0.992
PH0320
177aa long hypothetical phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
  
  
 0.991
PH0316
334aa long hypothetical phosphoribosylformylglycinamide cyclo-ligase; Similar to PIR:D64325 percent identity: 55.738 in 317aa; Swiss_Prot:P12043 percent identity: 42.679 in 335aa; Swiss_Prot:P43848 percent identity: 43.279 in 317aa.
  
 
 0.990
PH1117
220aa long hypothetical adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
   
 0.966
PH1955
227aa long hypothetical phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL an [...]
  
  
 0.965
PH0307
486aa long hypothetical inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
  
 0.962
Your Current Organism:
Pyrococcus horikoshii
NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.